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Rheumatology

General Rheumatology   

Questions discussed in this category

Is there any role for administering another course of recombinant zoster vaccine (Shingrx) in a previously vaccinated patient with RA, who is in clinical remission on Jak inhibitor but has had a breakthrough shingles infection?
Last SHINGRIX was about 4 years ago and both doses were given.
2 Answers available
In patients with diffuse scleroderma and symptomatic lower extremity venous insufficiency, would you recommend treatment with endovenous laser/ablation?
The patient has tried conservative measures with compression stockings.
1 Answer available
For patients with VEXAS syndrome and good response to azacitidine, what duration of therapy do you consider?
How do you decide to trial a patient off treatment? When do you consider spacing therapy and at what frequency?
1 Answer available
What are your practice recommendations regarding live vaccinations in infants/children of women who are currently on DMARDs and are breastfeeding?
Does the recommendation change based on the DMARD?
1 Answer available
How do you approach the management of recurrent episcleritis in a patient with RA that is otherwise well-controlled?
No active joint disease, patient on Hydroxychloroquine and Cimzia. Normal ESR/CRP.
1 Answer available
How would you treat an asymptomatic patient with a positive Blastomyces antibody, evidence of prior granulomatous lung disease on imaging, and who may require immunosuppression in the future?
1 Answer available
Do you recommend genetic screening for FMF in asymptomatic first-degree relatives with a strong family history (multiple family members, severe/refractory disease)?
1 Answer available
How do you approach managing nausea and GI side effects when initiating methotrexate?
3 Answers available
Do you routinely consider FDG PET/CT imaging for workup of fever of unknown origin?
1 Answer available
What is your approach to treatment of airway involvement, such as recurrent bronchial stenosis, in relapsing polychondritis?
Are there specific immunosuppressive agents effective for this manifestation?
1 Answer available
How do you treat idiopathic acute anterior uveitis that recurs immediately after a course of topical corticosteroids?
1 Answer available
What are the current treatment options for progressive multifocal leukoencephalopathy in patients without HIV/AIDS?
Are there any clinical trials underway to study additional therapies?
1 Answer available
How would you approach management of a patient with longstanding history of SLE, but having active psoriasis?
SLE manifestations include arthralgias and cytopenias which are stable. Previously did well on methotrexate, but developed GI side effects. HCQ is on ...
3 Answers available
What are some important considerations for use of ACE inhibition in scleroderma renal crisis patients who require dialysis?
For example, is captopril dialyzable? 
1 Answer available
Would you use the pneumococcal conjugate-21 vaccine (Capvaxive) instead of the conjugate-20 (Prevnar-20) for routine vaccinations in immunosuppressed patients?
2 Answers available
Can Dupixent (dupliumab) be safely used in patients who are taking other biologics for rheumatic disease?
1 Answer available
What is your approach to differentiating RA-ILD from medication toxicity (I.e. from methotrexate)?
1 Answer available
Is there a benefit to having a transition period in which a patient continues following with their previous pediatric rheumatologist while establishing care with a new adult rheumatologist?
What do adult rheumatologists need to understand about pediatric diseases? 
3 Answers available
How do you approach evaluation and management of a patient with recurrent monoarticular inflammatory arthritis of unclear etiology? 
Synovial fluid analysis: cell count >100,000, > 80% neutrophils. Gram stain, cultures (including fungal and mycobacterial), synovial biopsy, and...
2 Answers available
How do you counsel patients who experience diarrhea from mycophenolate mofetil (Cellcept)?
Do you generally recommend anti-diarrheals, dietary modifications, or consider this an unacceptable side effect and move to other therapies? 
2 Answers available
Is it necessary to prescribe a steroid taper after two weeks of high-dose prednisone (60 mg daily)?
4 Answers available
What is your workup and treatment approach for cranial neuropathies in patients with lupus?
1 Answer available
For patients with SLE, is there an ANC level for which you would hold or adjust hydroxychloroquine in an asymptomatic patient?
UpToDate recommends Hydroxychloroquine for all SLE patients, but neutropenia is sometimes ascribed to HCQ rather than the underlying disease. What lev...
2 Answers available
How long do you maintain patients with anti-synthetase syndrome on Rituximab?
The patient was treated with two doses of Rituximab and on MMF. Now with stable lung function and normalized CK.
2 Answers available
What would be the preferred treatment option for PMR if patient develops gastric perforation soon after initiation of steroids?
1 Answer available
How would you approach management of nodular scleritis in the setting of suspected GCA?
Can nodular scleritis be a presenting manifestation of GCA?
1 Answer available
How long do you treat retroperitoneal fibrosis with immunosuppression?
What imaging do you use to monitor disease activity? Imaging only shows chronic, fibrotic lesions making it hard to assess disease activity.
1 Answer available
What are some of the biggest challenges you run into when patients transition from pediatric to adult care?
1 Answer available
Should the age at which patients transition from pediatric to adult care differ depending on the disease diagnosis?
What nuances do adult rheumatologists need to understand about pediatric diseases? 
2 Answers available
Do you recommend adjusted adult cancer screening for patients who have been on long term biologics and/or tsDMARDs since childhood?
1 Answer available
How would you approach management of a patient with ESRD on the transplant list who is found to have high titer APS labs (ACL, B2GP1, LAC)?
1 Answer available
What are some strategies to help teach patients transitioning from pediatric to adult care to become more independent with respect to their care and less dependent on their caregivers?
1 Answer available
How do you discuss sexual health with pediatric patients transitioning to adult rheumatology care when the patient is accompanied by parents or caregiver?
1 Answer available
In a patient with low titer +anti-SAE antibody and known ILD, but no other clinical features of dermatomyositis, how would you approach further testing or would you treat the patient as dermatomyositis associated ILD?
1 Answer available
How often do you see bony erosions in patients with Lyme arthritis?
1 Answer available
What is your treatment approach for a young female who has an idiopathic small right elbow effusion with synovial thickening that has resulted in limitation in her range of motion?
1 Answer available
How do you approach a patient on anti-TNF with positive Quantiferon (previously negative) with negative chest x-ray and no symptoms?
7 Answers available
How do you approach use of DMARDs and/or biologics for inflammatory arthritis in patients with a history of seizure disorder on anti-epileptic medications?
Is there any concern for drug interactions of DMARDs and/or biologics with anti seizure medications?
1 Answer available
When would you consider using G-CSF in patients with rheumatic disease who have received cyclophosphamide?
2 Answers available
Do you perform genetic testing when patients have persistent hypogammaglobulinemia after rituximab therapy?
2 Answers available
Are there any concerns with live vaccine innoculation and patients who are on denosumab?
1 Answer available
How do you approach medication management in patients with RA when transitioning from csDMARD triple therapy to anti-TNF?
Which csDMARD do you taper in order, and is there a tapering strategy (duration/dose)?
2 Answers available
Are you comfortable with using NSAIDs in a patient on methotrexate for inflammatory arthritis?
Given the drug-drug interaction, do you monitor more closely for methotrexate toxicity, counsel on symptoms of methotrexate toxicity, or avoid the com...
2 Answers available
What is your approach to DVT prophylaxis in patients who require IVIG but are at increased risk for thrombotic events?
E.g., a patient with newly diagnosed CIDP who is wheelchair-bound.
2 Answers available
What is your approach to management of hyperlipidemia in patients taking JAK inhibitors?
1 Answer available
How would you approach management of a young male patient with discoid lupus who has had minimal response to hydroxychloroquine (and subtherapeutic whole blood levels) who continues to use tobacco products?
2 Answers available
Do you combine methotrexate and leflunomide for the treatment of RA?
3 Answers available
How do you manage a patient with cervical cancer who has FDG uptake in bilateral ischial tuberosities with lytic areas on CT correlate, and also has a history suspicious for untreated polymyalgia rheumatica with chronic symptoms in the same anatomic locations?
Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP. 
4 Answers available
What is the maximum dose of leucovorin that you use with methotrexate?
2 Answers available
Do you continue methotrexate in patients with inflammatory arthritis who develop non-melanomatous skin cancer while on therapy?
1 Answer available
In patients with sicca symptoms and positive SSA/SSB how often do you perform other diagnostic testing such as salivary gland ultrasound, biopsy, Shirmers, ocular staining, stimulated salivary flow, etc?
Is the diagnosis of Sjogren's mostly clinical in a patient with a consistent history and physical with positive serologies?
2 Answers available
How do you approach a patient with elevated bone specific ALP (>2X the normal limit), but no other evidence of Paget's disease?
Normal Vitamin D, bone scan showed osteoarthritis
1 Answer available
Is there a role for the use of transient elastography (FibroScan) to monitor liver fibrosis in patients on long term methotrexate?
3 Answers available
How would you manage cardiac sarcoid with intolerance/contraindications to methotrexate, azathioprine, and mycophenolate/mycophenolic acid and that has proven refractory to adalimumab and infliximab as determined by PET?
2 Answers available
Is there a role for nitazoxanide for treatment of norovirus gastroenteritis in immunocompromised patients?
1 Answer available
Would you switch azathioprine to a different immunosuppressant if a controlled patient with SLE develops melanoma and/or non-melanoma skin cancer?
2 Answers available
When considering a biologic for seropositive RA after failure of methotrexate or triple therapy, do you consider using abatacept as a first line biologic or would prefer choosing TNFi?
2 Answers available
In a patient with isolated HLA B27+ anterior uveitis, how long would you continue immunosuppressive therapy?
The patient has no extraocular features of a spondyloarthropathy and is on methotrexate. No active eye disease for past 1 year.
1 Answer available
Do you avoid hyaluronic acid injections in patients with chondrocalcinosis on imaging?
2 Answers available
How do you approach the work up of pulmonary artery aneurysm in the absence of other clinical features of Behcet’s?
1 Answer available
Do you find HZV titers useful in diagnosing shingles sine herpete?
1 Answer available
How would you approach management of a patient with checkpoint inhibitor induced psoriatic arthritis?
Pt with active skin and joint disease. Previously on Cemiplimab (PD-1) for squamous cell carcinoma of the skin. Do you avoid traditional DMARDs due to...
1 Answer available
What is your approach to differentiating tender spots (as in fibromyalgia) and enthesitis (as in axSpA)?
1 Answer available
What is your approach to work up for patients referred for early onset osteoarthritis?
1 Answer available
How do you approach work up for underlying rheumatologic disease in patients referred for chronic urticaria?
2 Answers available
When would you consider utilizing bone scintigraphy in the assessment of inflammatory arthritis?
2 Answers available
How are you utilizing vibratory devices for reducing pain associated with injection or procedures?
In which situations or patient populations do you find this useful? How is it sterilized?
3 Answers available
How do you approach treatment of a patient with active RA and a history of Lynch Syndrome?
Does your choice of DMARD/biologics change due to increased risk of malignancy?
1 Answer available
How do you utilize cytokine panels in your clinical practice?
Is there utility when classic inflammatory markers (ESR,CRP) or disease specific markers (C3, C4, dsDNA) do not correlate with patients disease activi...
1 Answer available
What is your approach to evaluation and management of a patient with Blau Syndrome and GI manifestations?
2 Answers available
How do you approach management of Adult Onset Still's disease in a patient with ongoing fatigue and inflammatory joint pain despite methotrexate, colchicine, canakinumab and tocilizumab?
Heritable autoinflammatory gene testing negative. Is there a role for TNF inhibitor?
3 Answers available
How do you decide when to obtain genetic testing for suspected autoinflammatory conditions in adults?
2 Answers available
How do you approach hypocomplementemia in Sjogren’s without features of lymphoma?
3 Answers available
Is there a risk of hepatitis C activation with rituximab in a patient who has a history of HCV treated with antivirals and who is in sustained viral response?
1 Answer available
Do you recommend sending an autoimmune work up for patients with recurrent nephrolithiasis and 24 hour urine chemistries consistent with distal renal tubular acidosis?
1 Answer available
Do you prefer celecoxib over a nonselective NSAID in patients with chronic kidney disease?
4 Answers available
What is your approach to counseling patients regarding re-initiation of anti-TNF therapy after completion of treatment for non-disseminated pulmonary histoplasmosis?
Would it be safe to resume and if so, when?
2 Answers available
For how long do you recommend treatment for latent tuberculosis prior to initiation of anti-TNF therapy?
6 Answers available
How do you monitor patients with incidentally found high titer anti-smooth muscle antibodies without stigmata of liver disease?
3 Answers available
How do you approach evaluation for underlying rheumatologic disease in patients with chronic asymptomatic thrombocytopenia?
Thrombocytopenia is moderate (80-100,000 microL). No concomitant cytopenias present.
2 Answers available
How do you approach management of adult patients with CVID and sarcoid-like syndrome?
1 Answer available
What is your approach to differentiating and managing DMARD-induced nodulosis (induced by methotrexate or leflunomide for example) from "de novo" RA nodules in seropositive RA patients?
1 Answer available
Do you restrict topical diclofenac use in your patients with chronic kidney disease?
3 Answers available
How do you approach patients referred for C1-2 pannus/erosions without clinical findings or serologies consistent with RA or CPPD arthropathy?
3 Answers available
Does your institution have formal policies or work flows to reduce unnecessary IGRAs ordered for patients on biologics?
1 Answer available
What do you recommend to patients when they are having an acute flare of fibromyalgia symptoms?
1 Answer available
What is your approach to monitoring for hepatic fibrosis in chronic methotrexate use?
Do you frequently order liver biopsies for these patients?This question is part of a collaboration with RheumMadness and is specifically in reference ...
2 Answers available
What isolation policies are Rheumatology offices employing for both staff and patients diagnosed with COVID-19 given the new CDC guidelines?
CDC Healthcare Guidance CDC Isolation and Work Restriction Guidance CDC Immunocompromised Guidance
1 Answer available
Is there utility in monitoring IgE levels in patients with IgG4-RD?
1 Answer available
Do you recommend Vitamin D and omega 3 fatty acid supplementation for prevention of autoimmune disease?
This question is part of a collaboration with RheumMadness and is specifically in reference to: Prevention of Autoimmune Disease: Vitamin D and O...
2 Answers available
What characteristics make a PMR patient a good candidate for sarilumab?
Do you plan to use sarilumab for all patients with relapsing or refractory PMR or are there certain features that will make you more or less likely to...
3 Answers available
How do you counsel and manage joint pain after isotretinoin treatment?
1 Answer available
What is your approach to a patient with IgG4RD with past pulmonary involvement (biopsy proven) managed with steroids alone, now with new hematuria/proteinuria, but stable renal function?
Would you obtain renal biopsy first or treat with additional immunosuppression for suspected renal involvement related to IgG4?
4 Answers available
How do you counsel patients on the use of topical nitroglycerin for Raynaud's?
What formulation of topical nitroglycerin do you use?
1 Answer available
How do you approach biologic initiation in patients with inflammatory arthritis and repeatedly indeterminate Quantiferon?
5 Answers available
How do you approach ongoing screening for TB in patients with a history of treated latent TB, but who have ongoing use of DMARDs and/or biologics given Quantiferon testing and PPD can remain positive?
How do you approach ongoing screening for TB in patients with history of treated latent TB, but have ongoing use of DMARDs and/or biologics given quan...
1 Answer available
Would you feel comfortable adding benlysta to patient already taking both mycophenolate and tacrolimus (and hydroxychloroquine) who still has some evidence of active lupus nephritis?
3 Answers available
What is your approach to working up diarrhea in an immunocompromised patient?
1 Answer available
Do you typically adjust or hold immunosuppression in a well-controlled RA patient who is being treated for Mycobacterium avium-intracellulare (MAI)?
1 Answer available
Do you avoid the use of hydroxychloroquine in patients with psoriasis and/or psoriatic arthritis?
1 Answer available
Do you have concerns with the use of oral contraceptives in patients on JAK inhibitors given the black box warning for thromboembolic events?
How has this impacted your counseling and management?
2 Answers available
What would be your approach to a patient with Scleroderma/Myositis overlap syndrome (+anti-Ku) and active inflammatory eye disease despite high dose mycophenolate?
2 Answers available
What else do you consider in the differential diagnosis for pulmonary-renal syndromes if there is low clinical and serologic evidence of AAV, Goodpasture's or other rheumatologic disease (SLE, RA, APS, Scleroderma)?
2 Answers available
Do you utilize post-vaccination IgG titers to detect common variable immunodeficiency in patients who are about to start or are actively on B cell depleting therapy?
2 Answers available
Do you counsel your patients on the potential decreased effectiveness of oral contraceptives while on Sarilumab?
If so, do you routinely recommend use of an additional form of contraception?
1 Answer available
How do you approach GI prophylaxis (e.g., PPIs, H2 blockers) in patients on long-term NSAIDs?
1 Answer available
How do you manage a patient with severe RA or SLE that worsens after stopping immunosuppressants due to having chronic foot ulceration?
2 Answers available
At what point do you consider a patient to have relapsing PMR?
How much cumulative prednisone exposure do you tolerate and how many attempts at tapering will you pursue before considering addition of a steroid spa...
4 Answers available
How do you approach follow up of young patients with isolated +ANA, but no current clinical signs or symptoms of SLE?
This question is part of a collaboration with RheumMadness and is specifically in reference to: Antibodies Before SLE.
6 Answers available
Do you typically screen patients for antiphospholipid antibodies in autoimmune diseases besides lupus in the absence of a clotting event?
6 Answers available
Do you consider anti-viral prophylaxis in patients taking JAK inhibitors who have recurrent uncomplicated Zoster infection, but would prefer not changing therapy?
2 Answers available
How do you approach management of a patient with persistent EBV infection and MAS despite treatment with Rituximab, anakinra and canakinumab? 
Would you consider alternative B cell depleting therapies such as ofatumumab or ocrelizumab?
1 Answer available
Does hepatitis B vaccination reduce the risk of HBV reactivation associated with immunosuppressive therapy?
For example, in patients who are HbSAg negative, anti-HBc positive and HbSAb negative, does vaccination reduce reactivation risk?
2 Answers available
How do you approach a negative ANA and positive dsDNA in patients with arthralgia, hair loss, or other UCTD features?
5 Answers available
Would a surgical decompression be indicated in a patient with amyloidosis and severe median neuropathy at the wrist?
1 Answer available
How do you approach management of a patient with idiopathic PAH and +ANA, but no other current symptoms/signs of active rheumatologic disease?
3 Answers available
Is it safe to combine mycophenolate and adalimumab for management of pulmonary sarcoidosis in a patient that could not tolerate methotrexate?
3 Answers available
How would you approach treatment of active inflammatory arthritis in a patient with MCTD (+RNP/+Chromatin) and stable ILD who has failed MMF, azathioprine and methotrexate?
Would you consider belimumab over a TNF inhibitor for inflammatory arthritis? Which agent would be more beneficial for the lung disease?
2 Answers available
At what point would you consider anticoagulation in a pregnant patient with lupus nephritis and non-nephrotic range proteinuria?
3 Answers available
How do you approach immunosuppression in patients with a positive Interferon Gamma Release Assay and prior intravesicular BCG treatment for bladder cancer?
Assuming no symptoms of TB, should patients be treated for latent TB prior to starting TNF inhibitors or other immunosuppressive agents?
1 Answer available
What treatment options do you recommend in a patient with idiopathic granulomatous mastitis that has not improved on steroids and methotrexate?
1 Answer available
Does IVIG or subcutaneous Ig interfere with monoclonal antibody therapy (i.e. dupilumab, infliximab, rituximab, etc)?
How should IVIG and either biologic injections or infusions be spaced?
2 Answers available
How will you approach tapering sarilumab in patients with PMR in remission?
After what interval of sustained remission will you attempt to taper, and will you do so by first widening the dosing interval?
2 Answers available
What are your top takeaways from ACR Convergence 2023?
2 Answers available
Do you have a preference between Quantiferon Gold and T-spot TB for screening in patients starting immunosuppressive agents?
1 Answer available
What is your approach to evaluation in patients who present with erythromelalgia?
1 Answer available
How will you approach drug sequencing in patients with PMR given the SAPHYR data?
Will you initiate sarilumab as a first steroid sparing agent or will you still pursue a DMARD such as methotrexate before initiating sarilumab? To wha...
2 Answers available
How will you adjust your approach to steroid taper in patients with PMR also on sarilumab?
2 Answers available
What baseline and ongoing testing do you recommend for patients with PMR who are going to be on a prolonged steroid taper?
Do you universally perform baseline DEXA and Hgb A1C? How often are you obtaining routine labs?
2 Answers available
How do you differentiate active vasculitis from pregnancy complications such as pre-eclampsia and HELLP in a patient with AAV?
3 Answers available
How do you approach the timing of Rituximab during pregnancy in a patient with life or organ threatening autoimmune disease?
3 Answers available
Is there a concern for the potential of future congenital malformations in offspring when preservation of eggs and sperm is done AFTER cyclophosphamide treatment given that it is an alkylating agent?
1 Answer available
In patients taking biologics who are planning joint replacement and are known MRSA carriers do you perform decolonization prior to surgery?
0 Answers available
Can joint replacement surgery be performed in someone with active Paget’s disease elsewhere?
1 Answer available
Do you stop TNF inhibitors during the third trimester of pregnancy?
2 Answers available
What is your approach to patients with severe sicca symptoms and history of B Cell lymphoma?
Patient has received treatment with Rituximab and is taking hydroxychloroquine.
1 Answer available
What is your approach to tapering chronic steroids in patients who are at high risk of HPA suppression?
For example, patients who have been maintained on 5mg of prednisone for years without previous tapering attempts and the rheumatic disease is not acti...
1 Answer available
How do you approach pre-conception counseling in males who are on medications for which there is limited or no data such as Jak inhibitors, apremilast, or belimumab?
2 Answers available
Do you hold rituximab for cataract surgery?
If so, when do you recommend timing for the cataract surgery? 
3 Answers available
How would approach the management of a patient with significantly positive anticardiolopin and beta 2 glycoprotein antibodies in the absence of any clotting (including obstetric) history but with significant thrombocytopenia (but no other features of active connective tissue disease)?
1 Answer available
How do you approach evaluation and management of arthralgia in a patient after CAR-T cell therapy?
1 Answer available
Have you seen drug induced SCLE from IL-17 inhibitors?
And if so, what is your approach to the diagnosis?
1 Answer available
How would you approach management of incidentally identified unilateral retinal vasculitis with subsequent labs revealing +P-ANCA?
Patient is asymptomatic. Labs showed +P-ANCA 1:160. Negative MPO and PR3.
2 Answers available
Is polymyalgia rheumatica associated with increased toxicity for lung SBRT?
1 Answer available
If a patient with relapsing remitting MS has comorbid Sjogren's syndrome and is on hydroxychloroquine (Plaquenil), how does that impact choice of DMT for MS?
1 Answer available
In a patient with active spondylarthritis and uveitis who cannot take TNF inhibitors, what is your next agent of choice?
1 Answer available
Would you consider a biologic or JAK inhibitor to manage active PsA in a patient on chronic antibiotic therapy if they had previously failed all conventional DMARDs (including apremilast)?
 Patient is on antibiotics for chronic spinal hardware infection.
1 Answer available
What is your approach to continuing or altering therapy when inheriting a patient with combined biologic immunosuppression that is in excess of guidelines?
How do you approach de-escalation or justify therapy maintenance? Do you have tiers of medications that you attempt to de-escalate first? In one parti...
1 Answer available
Would you have a patient temporarily discontinue methotrexate while receiving a FAST or FAST FORWARD regimen for breast irradiation?
The patient is on a dose of 22 mg of methotrexate weekly for severe rheumatoid arthritis. If you would discontinue the methotrexate, how long would y...
1 Answer available
What is your approach to management of chronic neutropenia in a patient with Sjogren’s who was recently diagnosed with metastatic endometrial cancer and plans to start chemotherapy?
ANC <500
1 Answer available
How do you manage patients with systemic sclerosis and chronic thrombotic microangiopathy on renal biopsy, but no other evidence of scleroderma renal crisis?
Patient with nephrotic range proteinuria, but there is no evidence of active TMA on renal biopsy.
1 Answer available
Do you find MRI helpful to differentiate early erosive OA from psoriatic arthritis when early X-ray changes in both conditions may be hard to distinguish?
1 Answer available
What is your approach to management of elevated liver enzymes in patients who recently started treatment with tocilizumab?
1 Answer available
How do you approach dosing of anakinra in MAS?
1 Answer available
What is your approach to evaluating a patient with known rheumatologic disease and elevated free kappa:lambda ratio, but no evidence of monoclonal immunoglobulins?
1 Answer available
What is your approach to rheumatologic disease management during the current methotrexate shortage? 
2 Answers available
How long would you wait to start another biologic agent after Rituximab administration in patients with dermatomyositis and refractory inflammatory arthritis (intolerant to traditional DMARDs)?
Patient with dermatomyositis on rituximab with refractory inflammatory arthritis. Intolerant of traditional DMARDs such as methotrexate, leflunomide, ...
1 Answer available
Would you consider re-irradiation for recurrence of Dupuytren's Contracture?
It's been 5+ years after the first course. If you decide to re-irradiate what dosing schema would you use?
2 Answers available
Do you use conventional DMARDs aside from methotrexate to prevent anti-drug antibody development for patients on infliximab?
This question is part of a collaboration with RheumMadness and is specifically in reference to: Etanercept + Methotrexate.
3 Answers available
How would you manage tubulointerstitial nephritis and renal tubular acidosis (RTA) in a patient with Sjogren's who is pregnant?
2 Answers available
What is the optimal timing for Zoster vaccine administration for a patient who recently recovered from herpes zoster infection and is now planning to start B-cell depletion therapy?
1 Answer available
What is your approach to elevated CK in patients without clinical or serologic evidence of immune mediated myopathy?
1 Answer available
Does synovial biopsy provide diagnostic value in undifferentiated inflammatory arthritis?
Apart from ruling out malignancy or infection?
1 Answer available
Is there any clinical benefit in referring patients with SLE or Sjogren's with cognitive impairment for neuropsychological testing?
How do you differentiate symptoms related to centralized pain syndrome from possible cognitive dysfunction?
2 Answers available
How do you counsel patients regarding alcohol intake when prescribing DMARDs other than methotrexate?
Such as Leflunomide, Sulfasalazine, Mycophenolate or Azathioprine, since all of these medications have potential to cause liver enzyme elevation and i...
1 Answer available
How do you approach management of patients with active RA and recurrent non-severe C.diff?
(Patient with active RA despite hydroxychloroquine)
1 Answer available
How do you manage injection site reactions in patients on subcutaneous biologics such as TNF inhibitors?
In what cases do you discontinue the medication?
2 Answers available
How long do you expect gastrointestinal side effects of leflunomide to persist after stopping treatment?
2 Answers available
Do you generally recommend starting nintedanib prior to immunosuppressive therapy in a patient with CTD-ILD?
Do you prefer to start with nintedanib and then add immunosuppressive agents, or give a trial of immunosuppressive medication first, then add nintedan...
4 Answers available
What would be the main indications for opting for biosimilars over an original biologic, outside of insurance barriers?
Are there any instances where you would prefer a biosimilar rather than the reference product? 
2 Answers available
Would you use TNF inhibitors in patients with features of SLE, but active peripheral and axial spondylarthritis?
Patient with sacroiliitis on imaging, failure of two NSAIDs.
2 Answers available
When tapering moderate to high doses of long term steroids do you routinely monitor for adrenal insufficiency?
Do you attempt to taper fully or maintain at a low dose?
2 Answers available
How do you approach the workup for a patient with persistently elevated inflammatory markers (CRP and ESR) whose history and exam do not point to a clear cause?
4 Answers available
Do you combine oral and topical NSAIDs for pain relief?
2 Answers available
Would you be comfortable using a JAK inhibitor in a patient with baseline thrombocytosis?
Would the etiology of the thrombocytosis play a role in your decision-making?
1 Answer available
What target do you utilize in clinical practice for defining disease remission in RA?
This question is part of a collaboration with RheumMadness and is specifically in reference to:BeSt TrialMeasurement of Patient Outcomes in Arthritis
1 Answer available
Do you recommend chlorhexidine mouth rinse for prophylaxis against oral complications in patients undergoing dental work who are immunosuppressed?
1 Answer available
Would you consider re-challenging a patient with rituximab after they experienced delayed neutropenia?
In a patient for whom rituximab is the best option for their disease management. 
2 Answers available
How do you differentiate the normal feeding vessel to the lunate from an erosion or power doppler signal on ultrasound?
1 Answer available
How do you counsel patients about the malignancy risk associated with azathioprine?
1 Answer available
Do you recommend patients continue folic acid for a few weeks after methotrexate discontinuation?
1 Answer available
How do you approach the usage of hydroxychloroquine in patients with rheumatologic conditions and baseline cardiomyopathy or heart failure?
1 Answer available
Do you continue to utilize ESR and CRP in patients on tocilizumab?
2 Answers available
How do you approach the use of hydroxychloroquine in patients with a history of visual field defect from another cause such as macular degeneration or diabetic retinopathy?
3 Answers available
Is there utility in obtaining pericardial fluid autoimmune labs such as ANA or RF in patients with recurrent idiopathic pericardial effusions, but no other clinical or serologic evidence of rheumatic disease?
1 Answer available
How do you approach evaluation of hypocomplementemia in a patient with arthralgias and a history of Hodgkin's lymphoma treated in the past?
ANA and ENA negative
1 Answer available
How do you manage severe Raynaud's phenomenon with ulceration in scleroderma patients that is refractory to oral agents (CCBs, PDEis, ARBs, and ERAs)?
2 Answers available
Is there any role of sympathectomy in Raynaud’s disease?
2 Answers available
How do you approach oral DMARD and/or biologic selection in patients with RA and a history of gastric bypass or whom are planning bariatric surgery?
1 Answer available
How do you counsel patients regarding contraception use while taking mycophenolate/mycophenolic acid?
2 Answers available
Would you consider use of belimumab in a patient with SLE with recurrent anterior uveitis who failed other treatment options?
Patient failed topical ocular therapies, methotrexate, azathioprine.
2 Answers available
In which clinical scenarios is relying on the urine protein-to-creatinine ratio as a measure of proteinuria unreliable, and interpretations should be made looking at urine protein and urine creatinine separately?
1 Answer available
How do you manage a patient with progressive cerebellar ataxia and positive cardiolipin antibodies?
Do you wait 12 weeks for confirmation to begin treatment if patient is declining?
1 Answer available
What is your approach to patients who present with unilateral Raynaud's?
3 Answers available
Do you typically see peripheral neuropathy in patients with castleman syndrome?
2 Answers available
How do you manage a patient with giant cell arteritis treated with weekly tocilizumab and low dose glucocorticoid who develops sudden vision loss?
2 Answers available
Is rituximab for refractory ITP contraindicated in the setting of an active COVID infection, particularly in a patient with asymptomatic COVID?
2 Answers available
What is your approach to the use of NSAIDs in patients with a history of gastric sleeve/bypass?
1 Answer available
How do you interpret elevations in ESR and CRP in the setting of increased BMI?
4 Answers available
When do you consider discontinuing Pegloticase in a patient with tophaceous gout who has had excellent response to therapy?
1 Answer available
What is your approach to patients with PMR on steroids over a prolonged initial course who start to experience weakness concerning for steroid myopathy?
1 Answer available
Do you discontinue or adjust azathioprine when a patient develops elevated MCV after starting it?
When it seems fairly certain that this is a drug effect is it something that can just be monitored or requires a change in approach?
2 Answers available
What is your approach to timing of medications like Rituximab and Cyclophosphamide around plasmapheresis in patients on daily PLEX?
4 Answers available
What is the appropriate management of arthralgias associated with bosutinib?
1 Answer available
How do you approach treatment of RA with methotrexate in a patient with treated Hepatitis C and normal liver function?
1 Answer available
How do you treat celiac disease associated inflammatory arthritis refractory to gluten free diet?
1 Answer available
Would you consider continuing a biologic for difficult to control autoimmune disease in a patient with a recent diagnosis of a surgically curable solid malignancy?
Would you favor the use of any particular biologics over others?
1 Answer available
Are there any concerns utilizing apremilast for psoriatic arthritis in patients who are also taking roflumilast for COPD?
1 Answer available
What are your top takeaways from ACR 2022?
4 Answers available
How do you approach the continued use of TNF inhibitors in a patient with inflammatory arthritis who develops a positive dsDNA without clinical evidence of drug-induced lupus?
2 Answers available
What is your approach to tapering therapy in a patient with recurrent pericarditis now well-controlled on rilonacept?
2 Answers available
How do you approach Covid vaccine counseling in patients with rheumatic disease and history of pericarditis/serositis?
1 Answer available
Do you recommend continuous antibiotic prophylaxis for patients on complement inhibitors such as eculizumab?
Do you just use antibiotic prophylaxis if therapy is started prior to meningococcal vaccination?
3 Answers available
How do you approach the workup of a patient with incidentally found pachymeningitis?
1 Answer available
What is your approach to using apremilast for psoriatic arthritis in patients with history of depression?
1 Answer available
How do you assess potential fetal harm in patients who have unplanned pregnancy while taking teratogenic medications?
1 Answer available
When considering the use of DOACs in APLS, does the number of positive APLS antibodies influence your decision?
2 Answers available
What is your treatment algorithm for management of retroperitoneal fibrosis that does not respond to high-dose glucocorticoids?
1 Answer available
When would you consider rituximab as induction therapy in IgG4-related disease?
4 Answers available
Do you avoid intra-articular and bursa/tendon sheath corticosteroid injections in patients with a history of avascular necrosis?
2 Answers available
How do you manage nausea in the setting of hydroxychloroquine use?
1 Answer available
Do you utilize ethyl chloride spray prior to steroid injections?
1 Answer available
Would you intensify therapy in IgG4 related disease based solely on a persistently significantly elevated IgG4 level when all disease manifestations and inflammatory markers have normalized?
1 Answer available
In patients who develop a VTE, what conditions do you consider as persistent, provoking risk factors, and at what point are they controlled enough to stop anticoagulation?
I.e., what constitutes well-controlled cancer, IBD, nephrotic syndrome, etc. What other diseases do you put in this category (obesity, autoimmune dise...
1 Answer available
How would you manage polymyalgia rheumatica refractory to prednisone, methotrexate and tocilizumab?
Patient has no current evidence of underlying vasculitis or malignancy.
2 Answers available
How do you evaluate patients who have panuveitis without any systemic symptoms?
1 Answer available
Do you refer all patients with a Beighton score over 5 to genetics for further assessment?
2 Answers available
Would you favor stopping hydralazine in a patient requiring it for refractory hypertension if they also have a high titer ANA in the absence of any SLE symptoms?
2 Answers available
What is the role of synovectomy in the diagnosis and management of patients with inflammatory arthritis?
1 Answer available
What is your approach to the workup for an underlying systemic condition in a patient presenting with retinal vasculitis?
1 Answer available
How do you evaluate livedo reticularis (not livideo racemosa)?
Does your evaluation hinge on nonresolution with warming? How extensive is your workup?
1 Answer available
When do you consider vascular imaging in patients with Raynaud's and what type of imaging modalities do you utilize?
1 Answer available
How do you manage psoriatic arthritis in patients who are planning to start treatment with checkpoint inhibitors for underlying malignancy?
2 Answers available
What is your approach to workup for an underlying disorder in a patient with bilateral hip avascular necrosis?
1 Answer available
How do you approach CV risk assessment in RA patients when RA itself is associated with some degree of increased CV risk at baseline?
Recent articles regarding the use of JAK-Inhibition in RA have suggested to avoid in patients with increased CV risk.  However, RA itself is cons...
2 Answers available
What is the role of non-prednisone oral glucocorticoids in the management of systemic rheumatologic disease?
Such as oral methylprednisolone, dexamethasone, prednisolone, etc.
1 Answer available
Which medications have the lowest risk of tuberculosis reactivation in patients with uncertain tuberculosis history and active rheumatologic disease?
2 Answers available
What is the difference between Multisystem Inflammatory Syndrome in Adults (MIS-A) and MAS/HLH?
1 Answer available
Does calcinosis appear differently in patients with dermatomyositis compared to systemic sclerosis?
1 Answer available
Do you treat fibromyalgia in your practice or do you refer back to PCP after ruling out autoimmune inflammatory pathology?
3 Answers available
How do you utilize methotrexate and/or hydroxychloroquine in the setting of limited scleroderma/CREST?
1 Answer available
Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
1 Answer available
Is there a role for regular hepatitis and TB screening in patients on chronic immunosuppressive therapy in the absence of new risk factors or exposures?
1 Answer available
Are there any known contraindications for IL-23 use in patients with psoriatic arthritis and CKD or ESRD?
1 Answer available
How do you think about biologic use in patients with underlying HIV infection?
2 Answers available
Do you hold tocilizumab for patients who are diagnosed with Covid and are with mild to moderate symptoms or non-hospitalized?
1 Answer available
What is your approach to evaluation of underlying autoimmune disease in patients with bilateral scleromalacia?
1 Answer available
How do you treat post-IVIG headache that is not responsive to Tylenol or NSAIDs?
Specifically, how do you treat the delayed headache, not the headache that develops during the infusion where pre-hydration and slowing down the rate ...
4 Answers available
Is there a role for prednisolone over prednisone in rheumatic patients with hepatic impairment?
1 Answer available
When a patient with a preexisting rheumatic disease and on immunotherapy begins to flare, how do you decide if this is an underlying rheumatic disease activity versus an immunotherapy related adverse event?
How do you decide if it may be safe to continue immunotherapy?
1 Answer available
Given the "LDL Paradox", in which RA patients with the highest levels of inflammation can have ultra-low levels of LDL (<70), how do you approach initiation of statin therapy in these patients?
Dr. Charles-Schoeman presented data at ACR 21 showing that, paradoxically, there is a U-shaped relationship between inflammation and LDL levels in pat...
1 Answer available
Is there a role for antibody testing to confirm vaccine response for patients on rituximab after COVID-19 vaccination?
1 Answer available
When would you consider checking JC virus prior to initiating biologic therapy?
1 Answer available
How will you use REGEN-COV (casirivimab/imdevimab-monoclonal antibody treatment recently approved under EUA as post-exposure prophylaxis for Covid) in rheumatic patients on immunosuppressive therapy?
Would you consider this for patients on B-cell depleting therapies or more broadly for other immunosuppressive agents?
2 Answers available
What is your management approach for patients with Adult Onset Still's who are planning pregnancy?
1 Answer available
What are your recommendations regarding methotrexate usage in patients with persistent chest CT changes post COVID pneumonia?
Would you have a different opinion based on whether it is a new therapy or an existing and previously well-tolerated therapy for the patient?
2 Answers available
How do you diagnose and treat patients who develop uveitis while on bisphosphonate therapy for osteoporosis?
Are there specific features that suggest drug-induced uveitis versus de novo uveitis?
1 Answer available
How are you timing the third dose of the COVID-19 mRNA vaccine in patients on rituximab?
1 Answer available
What is your differential for a patient presenting with multiple digits affected by flexor tenosynovitis, dupuytren's, and no evidence of peripheral inflammatory arthritis?
1 Answer available
How do you approach folate supplementation for methotrexate-related side effects?
3 Answers available
What is your approach to monitoring lipids in patients with rheumatic diseases such as RA and SLE and do you have a lower threshold to start lipid lowering agents compared to the general population?
2 Answers available
Are there any specific circumstances when you would consider the use of immunosuppression for DISH?
There is some emerging evidence that there is an inflammatory component. 
1 Answer available
How would you counsel a patient who is interested in using supplements (such as fish oil or turmeric) as an adjunct to treatment of inflammatory arthritis?
3 Answers available
How do you approach the treatment of eosinophilic fasciitis refractory to glucocorticoids and methotrexate?
1 Answer available
Would you consider using a TNFi in a patient with a family history of demyelinating disease, in the absence of a personal history?
2 Answers available
How do you approach management of patients with inflammatory arthritis who are asymptomatic but develop radiographic progression?
1 Answer available
What is your threshold for number of alcoholic drinks per week before reconsidering prescribing methotrexate/leflunomide?
1 Answer available
How do you approach the use of biologics in patients with a history of Guillain-Barre syndrome?
1 Answer available
What is your approach to managing abnormal lipids in a patient on tocilizumab?
1 Answer available
How do you approach the treatment of inflammatory polyarthritis in patients with myelodysplastic syndromes?
2 Answers available
How do you approach the evaluation of patients referred for chronic lyme disease and counsel patients regarding this entity?
1 Answer available
Do you extrapolate from uveitis treatment pathways when managing other inflammatory eye conditions such as atypical serpiginous choroiditis?
2 Answers available
Do you switch to certolizumab in RA patients who are doing well on other TNFis and planning to become pregnant?
1 Answer available
How does a history of splenectomy alter how you counsel patients on the infection risk of TNF inhibitors or other biologics?
1 Answer available
Are you recommending the mRNA COVID-19 vaccines to your patients with immune mediated inflammatory diseases?
5 Answers available
Do you recommend shingles vaccine to all immunosuppressed patients under the age of 50 y.o.?
1 Answer available
Do you correct the synovial fluid white blood cell count for red blood cells, and if so, is there a rough approximation/equation you use?
2 Answers available
How do you approach patients with overlapping features of PMR and seronegative RA?
1 Answer available
How do you handle hypogammaglobulinemia detected in patients prior to maintenance rituximab infusion?
2 Answers available
Would you hold all immunosuppressive medications for the first month of LTBI treatment, or just biologics?
1 Answer available
How do you interpret a high positive RNP in the setting of a negative ANA and negative sm/RNP?
To my understanding, sm/RNP should also be positive in this situation (and one would assume a positive ANA as well)
1 Answer available
Is there an increased risk of COVID-19 in patients on immunosuppressants?
1 Answer available
Do you avoid any specific biologic therapies in HIV positive patients?
1 Answer available
What is your inflammatory arthritis differential when a patient presents with unilateral TMJ synovitis?
2 Answers available
What are examples of rheumatology quality measures that are both clinically meaningful and can be captured accurately and efficiently?
1 Answer available
Which steroid-sparing agent do you prefer to treat multi-organ Sweet's syndrome?
1 Answer available
Do you follow patients with elevated ESR/CRP if their work-up for rheumatologic etiology is unrevealing and no other cause is identified?
2 Answers available
What would be your differential for a wrist monoarthritis in an elderly female with erosions on MRI after less than 3 months of symptoms?
1 Answer available
How do you manage patients who are Hepatitis B core antibody positive/surface antigen negative and starting a biologic DMARD (other than rituximab)?
1 Answer available
Is there a role for tocilizumab in treatment of polymyalgia rheumatica in patients who do not have features of giant cell arteritis or rheumatoid arthritis?
1 Answer available
Are there any clinical situations in which checking for anti-chromatin antibodies is helpful?
1 Answer available


Papers discussed in this category

Arthritis Rheumatol, 2016 Jan
2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
Arthritis and rheumatism, 1982-11
The 1982 revised criteria for the classification of systemic lupus erythematosus.
Arthritis and rheumatism, 2012-08
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus.
, 2019 Aug 06
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus.
Arthritis Rheum.,
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus.
,
Brief Report: A Prospective Open-Label Phase IIa Trial of Tocilizumab in the Treatment of Polymyalgia Rheumatica.
Arthritis care & research, 2017-03
Rates of Serious Infections in HIV-Infected Patients Receiving Tumor Necrosis Factor Inhibitor Therapy for Concomitant Autoimmune Diseases.
Clin Exp Dermatol, 2018 May 24
Treatment of psoriasis with ustekinumab in a patient with HIV-related Kaposi sarcoma.
Eur J Rheumatol, 2017 Feb 23
Management of the temporomandibular joint in inflammatory arthritis: Involvement of surgical procedures.
Rev Bras Reumatol Engl Ed, 2016 Mar 16
What rheumatologists should know about orofacial manifestations of autoimmune rheumatic diseases.
Southern medical journal, 2016-11
Effects of Statin Therapy in Patients with Systemic Lupus Erythematosus.
Annals of the rheumatic diseases, 2011-05
Lupus Atherosclerosis Prevention Study (LAPS).
Atherosclerosis, 2015 Aug 28
Statin reduces mortality and morbidity in systemic lupus erythematosus patients with hyperlipidemia: A nationwide population-based cohort study.
N Engl J Med, 2020 Apr 29
Covid-19 in Immune-Mediated Inflammatory Diseases - Case Series from New York.
JAMA network open, 2018-11-02
Association of Immunoglobulin Levels, Infectious Risk, and Mortality With Rituximab and Hypogammaglobulinemia.
The Journal of arthroplasty, 2008-02
Determining "true" leukocytosis in bloody joint aspiration.
N Engl J Med,
Clinical practice. Care of the asplenic patient.
Mediterr J Rheumatol, 2020 Jun 11
Infections in Patients with Rheumatoid Arthritis in the Era of Targeted Synthetic Therapies.
Clin Infect Dis,
Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.
Cochrane Database Syst Rev, 2013 May 31
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
British journal of cancer, 2023 Feb 04
Use of methotrexate and risk of skin cancer: a nationwide case-control study.
Ann Rheum Dis, 2017 Mar 23
Quantifying the hepatotoxic risk of alcohol consumption in patients with rheumatoid arthritis taking methotrexate.
Clin Pharmacokinet,
Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids.
Gut,
Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis.
Arthritis and rheumatism, 2001-12
Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides.
J Med Food,
Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Int J Clin Pract, 2021 Apr 29
Curcumin and rheumatoid arthritis: A systematic review of literature.
Nutrients, 2020 Dec 11
Efficacy of Spice Supplementation in Rheumatoid Arthritis: A Systematic Literature Review.
Current rheumatology reports, 2009-10
Diffuse idiopathic skeletal hyperostosis: differentiation from ankylosing spondylitis.
Radiology,
Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH).
Curr Rheumatol Rep, 2021 Jan 26
Diffuse Idiopathic Skeletal Hyperostosis (DISH) and a Possible Inflammatory Component.
Kidney international, 2009-12
A prospective study of protein excretion using short-interval timed urine collections in patients with lupus nephritis.
Clinical journal of the American Society of Nephrology : CJASN, 2010-07
Comparison of urinary albumin-creatinine ratio and albumin excretion rate in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications study.
Journal of the American Society of Nephrology : JASN, 2010-08
Comparison of different measures of urinary protein excretion for prediction of renal events.
Am J Kidney Dis, 2016 Sep 16
Timed Urine Collections for Albumin and Protein: "The King Is Dead, Long Live the King!".
J Rheumatol, 2004 Aug
Urine protein-to-creatinine ratio is a reliable measure of proteinuria in lupus nephritis.
N Engl J Med, 2021 Aug 04
Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19.
Curr Opin Rheumatol,
Retinal vasculitis.
BMJ Open, 2019 May 05
Is incident rheumatoid arthritis interstitial lung disease associated with methotrexate treatment? Results from a multivariate analysis in the ERAS and ERAN inception cohorts.
Rheumatol Int, 2021 Jan 29
Does methotrexate cause progressive fibrotic interstitial lung disease? A systematic review.
Rheumatology (Oxford),
Five successful pregnancies with antenatal anakinra exposure.
Z Rheumatol,
[IL-1-blockade with Anakinra during pregnancy : Retrospective analysis of efficacy and safety in female patients with familial Mediterranean fever].
Journal of neurovirology, 2018-06
Progressive multifocal leukoencephalopathy in rituximab-treated rheumatic diseases: a rare event.
Blood Adv,
American Society of Hematology 2020 guidelines for management of venous thromboembolism: treatment of deep vein thrombosis and pulmonary embolism.
Annals of the rheumatic diseases, 2012-08
Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response.
Lupus,
Hydroxychloroquine use predicts complete renal remission within 12 months among patients treated with mycophenolate mofetil therapy for membranous lupus nephritis.
Arthritis Rheumatol, 2020 Jan 07
Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy.
J Rheumatol, 2013 Nov 15
Experiences with rituximab for the treatment of autoimmune diseases with ocular involvement.
Arthritis Res Ther, 2005 Mar 01
Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey.
JAMA Ophthalmol, 2015 Oct
Association of systemic lupus erythematosus with uveitis.
JAMA, 2022 Oct 11
Hydroxychloroquine Dose per Ophthalmology Guidelines and the Risk of Systemic Lupus Erythematosus Flares.
Front Immunol, 2021 May 14
A Review of the Various Roles and Participation Levels of B-Cells in Non-Infectious Uveitis.
J Rheumatol, 2019 Apr 01
Therapy with Biologic Agents After Diagnosis of Solid Malignancies: Results from the Corrona Registry.
RMD Open,
How do we use biologics in rheumatoid arthritis patients with a history of malignancy? An assessment of treatment patterns using Scandinavian registers.
Curr Med Chem,
Targeting IL-17 and IL-23 in Immune Mediated Renal Disease.
Pathology, 2017 Mar 11
The role of interleukin-17A in the pathogenesis of kidney diseases.
Lancet,
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial.
The Lancet. Respiratory medicine, 2016-09
Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial.
Annals of the rheumatic diseases, 2015-06
Rituximab for IgG4-related disease: a prospective, open-label trial.
Neth J Med,
The treatment outcomes in IgG4-related disease.
Medicine (Baltimore),
Therapeutic approach to IgG4-related disease: A systematic review.
Ann Rheum Dis, 2016 Oct 03
EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update.
ACR Open Rheumatol, 2021 Aug 25
Performance of Cytokine Storm Syndrome Scoring Systems in Pediatric COVID-19 and Multisystem Inflammatory Syndrome in Children.
Arthritis Res Ther, 2021 Mar 22
Vision loss in patients with giant cell arteritis treated with tocilizumab.
Scientific reports, 2017 Aug 10
Analysis of Factors Influencing Diagnostic Accuracy of T-SPOT.TB for Active Tuberculosis in Clinical Practice.
J Orthop Translat, 2020 Jan 06
Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version).
Annals of internal medicine, 2018-01-16
Use of Immune Checkpoint Inhibitors in the Treatment of Patients With Cancer and Preexisting Autoimmune Disease: A Systematic Review.
J Immunother Cancer,
Combination anti-PD1 and ipilimumab therapy in patients with advanced melanoma and pre-existing autoimmune disorders.
Autoimmun Rev, 2012 Nov 30
Immunogenicity and autoimmunity during anti-TNF therapy.
Arthritis Rheum,
Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis.
Arthritis care & research, 2014-08
Identification of risk factors for elevated transaminases in methotrexate users through an electronic health record.
Intern Med J, 2022 Mar 16
Assessment of liver fibrosis markers in people with rheumatoid arthritis on methotrexate.
Ann Rheum Dis, 2016 Feb 17
The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation.
Support Care Cancer, 2019 Dec 13
Effects of ginger adjunct to the standard prophylaxis on reducing carboplatin and paclitaxel-induced nausea vomiting: a randomized controlled study.
Int J Surg Case Rep, 2020 Nov 22
Destructive Osteonecrosis of the Femoral Head After a Single Intra-Articular Corticosteroid Injection: A Report of Two Cases.
Eur J Orthop Surg Traumatol, 2019 Sep 19
Avascular necrosis of the femoral head after single steroid intra-articular injection.
Annals of the rheumatic diseases, 2019-10
EULAR recommendations for the management of antiphospholipid syndrome in adults.
J Thromb Haemost, 2020 Nov 29
Trial of Rivaroxaban in AntiPhospholipid Syndrome (TRAPS): Two-year outcomes after the study closure.
Front Cardiovasc Med, 2021 Aug 03
Use of Direct Oral Anticoagulants in Patients With Antiphospholipid Syndrome: A Systematic Review and Comparison of the International Guidelines.
Medizinische Klinik (Munich, Germany : 1983), 2002-11-15
[Prevalence of circulating autoantibodies in healthy individuals].
Journal for scientific research. Medical sciences, 2001 Apr
Occurence of autoantibodies in healthy Omani individuals.
Clin Microbiol Infect, 2018 Feb 07
ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Introduction).
Arthritis & rheumatology (Hoboken, N.J.), 2018-03
The Science Behind Biosimilars: Entering a New Era of Biologic Therapy.
N Engl J Med, 2020 Nov 16
Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis.
Clinical pharmacokinetics, 2018-12
Infliximab Pharmacokinetics are Influenced by Intravenous Immunoglobulin Administration in Patients with Kawasaki Disease.
Frontiers in immunology, 2018
Reversing Autoimmunity Combination of Rituximab and Intravenous Immunoglobulin.
Clinical immunology (Orlando, Fla.), 2020 Jul 15
The potential impact of timing of IVIG administration on the efficacy of rituximab for immune tolerance induction for patients with Pompe disease.
The Pediatric infectious disease journal, 2018 Oct
Infliximab Plus Intravenous Immunoglobulin (IVIG) Versus IVIG Alone as Initial Therapy in Children With Kawasaki Disease Presenting With Coronary Artery Lesions: Is Dual Therapy More Effective?
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2017 Nov 03
Successful IVIG treatment without discontinuation of TNF-α blocker in Guillain-Barre syndrome induced by adalimumab in patient with Crohn's disease.
N Engl J Med,
Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis.
Ann Rheum Dis, 2022 Sep 22
Risk of major adverse cardiovascular events with tofacitinib versus tumour necrosis factor inhibitors in patients with rheumatoid arthritis with or without a history of atherosclerotic cardiovascular disease: a post hoc analysis from ORAL Surveillance.
Rheumatology (Oxford), 2014 Sep 16
Differentiation between osteoarthritis and psoriatic arthritis: implications for pathogenesis and treatment in the biologic therapy era.
Current medical research and opinion, 2016-12
Corticosteroids: the knee jerk response.
Open access rheumatology : research and reviews, 2016
Polymyalgia rheumatica: observations of disease evolution without corticosteroid treatment.
PET Clin, 2020 Feb 11
18F-Fluorodeoxyglucose PET/Computed Tomography in the Diagnosis and Monitoring of Giant Cell Arteritis.
Rheumatology (Oxford), 2022 Jul 22
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis.
Arthritis and rheumatism, 2008-09
Reduction of plasma urate levels following treatment with multiple doses of pegloticase (polyethylene glycol-conjugated uricase) in patients with treatment-failure gout: results of a phase II randomized study.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2014-12
Infusion-related reactions with pegloticase, a recombinant uricase for the treatment of chronic gout refractory to conventional therapy.
Curr Rheumatol Rep, 2022 Feb 15
Expert Opinion on Pegloticase with Concomitant Immunomodulatory Therapy in the Treatment of Uncontrolled Gout to Improve Efficacy, Safety, and Durability of Response.
Arthritis Care Res (Hoboken), 2017 Dec
Impact of Obesity and Adiposity on Inflammatory Markers in Patients With Rheumatoid Arthritis.
JAMA, 1999 Dec 08
Elevated C-reactive protein levels in overweight and obese adults.
Reumatologia, 2020 Feb 28
The impact of obesity on inflammatory markers used in the assessment of disease activity in rheumatoid arthritis - a cross-sectional study.
Pediatr Blood Cancer, 2021 Oct
Idiopathic multicentric Castleman disease with TAFRO clinical subtype responsive to IL-6/JAK inhibition: A pediatric case series.
Int. J. Radiat. Oncol. Biol. Phys.,
Radiotherapy optimization in early-stage Dupuytren's contracture: first results of a randomized clinical study.
The New England journal of medicine, 2003-10-16
Development of autoantibodies before the clinical onset of systemic lupus erythematosus.
Rheumatology (Oxford, England), 2018-09-01
The SLE-key test serological signature: new insights into the course of lupus.
Lupus, 2021 Jan 05
Delayed diagnosis adversely affects outcome in systemic lupus erythematosus: Cross sectional analysis of the LuLa cohort.
Arthritis Rheumatol, 2018 Jun 27
Brief Report: Lupus-An Unrecognized Leading Cause of Death in Young Females: A Population-Based Study Using Nationwide Death Certificates, 2000-2015.
J Manag Care Spec Pharm, 2022 Jul 01
Complement activation products vs standard ANA testing: Treatment outcomes, diagnosis, and economic impact (CAPSTONE) in systemic lupus erythematosus.
Diagnostics (Basel), 2021 Sep 01
Anti-DFS70 Antibodies for Differentiating Systemic Autoimmune Rheumatic Disease in Patients with Positive ANA Tests: A Systematic Review and Meta-Analysis.
Front Immunol, 2021 May 27
Autoantibody Discovery, Assay Development and Adoption: Death Valley, the Sea of Survival and Beyond.
Chest, 2021 Feb
Consensus Guidelines for Evaluation and Management of Pulmonary Disease in Sjögren's.
Expert review of clinical immunology, 2015 Dec 22
Early diagnosis of primary Sjögren's syndrome: EULAR-SS task force clinical recommendations.
The neurologist, 2017 Jul
Spectrum of Autonomic Nervous System Impairment in Sjögren Syndrome.
Arthritis Rheumatol, 2020 Apr
2020 American College of Rheumatology Guideline for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases.
Immunol Invest, 1985 Jun
Specificity of the Crithidia luciliae method for detecting anti-DNA antibodies. Effect of absorption for lipoproteins.
Int J Environ Res Public Health, 2021 Aug 01
Relationship of Hydroxychloroquine and Ophthalmic Complications in Patients with Type 2 Diabetes in Taiwan.
Arthritis Care Res (Hoboken), 2023 Feb 10
Occam's Razor Dulled: A Curious Case of Dyspnea in a 70-Year-Old.
J Am Dent Assoc, 2016 Jan 05
Clinical practice guidelines for oral management of Sjögren disease: Dental caries prevention.
Eur J Radiol, 2020 Jan 17
Ultrasound characterization of pseudoerosions and dorsal joint recess morphology of the hand and wrist in 100 asymptomatic subjects.
Joint Bone Spine, 2019 Jan 31
Ultrasonographic criteria for the diagnosis of erosive rheumatoid arthritis using osteoarthritic patients as controls compared to validated radiographic criteria.
Arthritis Rheumatol, 2020 Sep 6
Incidence, Clinical Features, and Outcomes of Late-Onset Neutropenia From Rituximab for Autoimmune Disease.
Arthritis and rheumatism, 2011-03
Evaluation of the safety of rituximab in combination with a tumor necrosis factor inhibitor and methotrexate in patients with active rheumatoid arthritis: results from a randomized controlled trial.
The Journal of rheumatology, 2013-05
Safety of rituximab in combination with other biologic disease-modifying antirheumatic drugs in rheumatoid arthritis: an open-label study.
Arthritis & rheumatology (Hoboken, N.J.), 2017-10
The Safety and Immunogenicity of Live Zoster Vaccination in Patients With Rheumatoid Arthritis Before Starting Tofacitinib: A Randomized Phase II Trial.
Arthritis Rheum, 2004 Oct
Safety and efficacy of tumor necrosis factor alpha blockade in systemic lupus erythematosus: an open-label study.
N. Engl. J. Med., 2019 May 20
Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.
N Engl J Med, 2019 Sep 29
Nintedanib in Progressive Fibrosing Interstitial Lung Diseases.
Ther Adv Musculoskelet Dis, 2020 Nov 24
Efficacy of high-dose anakinra in refractory macrophage activation syndrome in adult-onset Still's disease: when dosage matters in overcoming secondary therapy resistance.
Blood advances, 2024 Aug 13
Long-term outcomes of peripheral blood stem cell unrelated donors mobilized with filgrastim.
Annals of oncology : official journal of the European Society for Medical Oncology, 2018 Sep 01
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