theMednetRegister

Medical Oncology

Gynecologic Cancers   

Questions discussed in this category

How would you treat IIB ovarian carcinosarcoma which recurred locally at 1 month post initial debulking surgery, progressed through 2 cycles of adjuvant carbo/taxol, and is now s/p repeat debulking?
Tumor is HER2 3+ on IHC staining.
1 Answer available
How do you treat a locally advanced cervix cancer in a patient who declines brachytherapy?
What are your volumes and dose/fractionation for external beam boost in lieu of tandem and ovoid or tandem and ring implant?
8 Answers available
In a patient with serous ovarian adenocarcinoma who presents with SBO due to focal involvement of the small bowel, but who has other extensive metastases and cannot get chemotherapy due to bone marrow compromise, would you recommend palliative RT in addition to venting G-tube placement?
What is the reasonable expected benefit to be gained, if any? 
1 Answer available
What adjuvant treatment would you recommend for a patient with FIGO 2023 IIIB2 endometrioid endometrial adenocarcinoma (Grade 3, p53mut, MMR proficient), metastatic to the uterine serosa, bilateral ovaries, and anterior peritoneal reflection?
What do you think is the role of radiation for this patient and how should it be timed?
3 Answers available
Do you recommend progesterone for endometrial protection in a young woman on estrogen replacement therapy for iatrogenic menopause after definitive radiation therapy for locally advanced cervical cancer?
If so, what do you typically prescribe?
2 Answers available
How would you sequence adjuvant chemo-immunotherapy (paclitaxel/carbo/pembro or paclitaxel/carbo/dostarlimab) with EBRT and vaginal cuff brachytherapy in advanced uterine cancer that meets clinical criteria for both EBRT and chemo-IO?
2 Answers available
How would you manage a POLE mutated, p53 abnormal IA myoinvasive carcinosarcoma of the endometrium with no LVSI?
Do you offer observation for POLE mutated tumors?
3 Answers available
What are your top takeaways in Gyn Cancers from ESMO 2024?
1 Answer available
Would you add olaparib to maintenance immunotherapy for a patient with recurrent MMR-proficient, HER2-negative serous endometrial carcinoma?
1 Answer available
Given the negative results of GOG-0238 but the positive results of the RUBY trial, how do you manage isolated vaginal cuff recurrence of endometrial cancer?
Would you consider the addition of carboplatin/paclitaxel + dostarlimab to radiation as opposed to radiation alone?
1 Answer available
How would you manage a cervical cancer patient with bulky PA LNs with direct extension and/or invasion into the lumbar vertebral bodies?
Would you consider this stage IVA (spread to adjacent organ) or IVB (spread to distant organ)? For instance, would the presence of direct lumbar verte...
4 Answers available
What are your top takeaways from SGO 2022?
10 Answers available
Should I treat a patient who doesn't know she has cancer?
My patient’s family has asked that I don’t tell her that she has metastatic cancer because it will devastate her. I am planning on palliat...
4 Answers available
How do you counsel patients with locally advanced malignancies who have ECOG 3-4?
How do you advise patients who strongly desire chemotherapy?
4 Answers available
Would you recommend surgery or stereotactic radiation therapy for a young woman with high-grade serous ovarian cancer presenting with a pelvic LN oligometastasis following maintenance therapy?
1 Answer available
How do you manage a patient with cervical cancer who has FDG uptake in bilateral ischial tuberosities with lytic areas on CT correlate, and also has a history suspicious for untreated polymyalgia rheumatica with chronic symptoms in the same anatomic locations?
Cervical cancer FIGO stage IIIC2. Bloodwork shows elevated ESR and CRP. 
4 Answers available
Would you transition from denosumab to anabolic agents in patients who are in urgent need for extensive dental work?
2 Answers available
In patients with recurrent endometrial carcinoma, how do you decide when to offer Carboplatin/Paclitaxel +/- pembrolizumab or dostarlimab (NRG-GY018/RUBY) versus Lenvatinib/Pembrolizumab (KEYNOTE-775)?
1 Answer available
How would you manage a recurrent cervical cancer previously treated with vaginal cuff brachytherapy and has had a complete response to chemo-immunotherapy?
The 4 cm cuff recurrence occurred 3 years after definitive treatment with hysterectomy and vaginal cuff brachytherapy to 21 Gy. The recurrence had a c...
3 Answers available
How would you palliate a large, symptomatic vaginal melanoma recurrence with limited small pelvic lymph node metastases?
Would your management change given that this recurrent lesion is over 10 cm and the patient previously achieved complete response on immunotherapy 5 y...
3 Answers available
How do you approach adjuvant treatment of non-uterine leiomyosarcoma?
When, if ever, do you utilize adjuvant RT or chemotherapy?
2 Answers available
What are your top takeaways in Gyn Cancers from ASCO 2024?
3 Answers available
Do you recommend concurrent cisplatin and gemcitabine with radiotherapy for unresectable vulvar cancer, as described in GOG-279?
2 Answers available
Would you offer adjuvant systemic therapy for recurrent fallopian tube leiomyosarcoma after resection of an isolated liver metastasis that presented within 1 year from primary surgery?
1 Answer available
For a patient with IIIC1 (micromets), MSI-high, Grade 2 endometrial adenocarcinoma who has undergone full surgical staging, do you recommend adding immunotherapy to adjuvant chemotherapy + radiation?
2 Answers available
Do you typically recommend avoiding neupogen during radiation treatments?
6 Answers available
What are your top takeaways from SGO 2024?
2 Answers available
How do you counsel patients and partners of patients with HPV+ cancers regarding the HPV vaccine?
This would apply to gynecologic and GI cancers as well. And as long as the patient's partner is within the recommend age of <45 yo
1 Answer available
What are magic mouthwash alternatives that you would recommend?
There was a recall on viscous lidocaine and many of our patients cannot find it. What would you recommend as alternatives?
9 Answers available
Should all patients with a remote history of immunotherapy, chemotherapy and/or radiation therapy have a baseline TTE regardless of ASCVD risk?
2 Answers available
How would you treat a p16+ squamous cell carcinoma confined in the recto-vaginal septum with no suspicious adenopathy on PET or MRI?
The patient is a female in her 40s. No mucosal changes were evidenced on clinical exam. Chemo-RT is recommended by GynOnc at an academic center. ...
6 Answers available
What would you offer a patient with MSI-high metastatic endometrial cancer after disease progression on pembrolizumab?
The patient was initially treated with Carboplatin/Paclitaxel and progressed after 1 year. She was switched to pembrolizumab and had significant progr...
1 Answer available
What do you view as the future role for the combination of durvalumab + olaparib + chemotherapy in the management of patients with advanced/recurrent endometrial cancer following the DUO-E trial results?
Are there certain patient subgroups for whom you would use the IO+PARPi? Is there data from DUO-E regarding BRCA status and its potential impact on ...
2 Answers available
In light of the improved outcomes seen in patients receiving IO +/- olaparib, what role, if any, do you think pelvic radiation still plays in the management of patients with advanced endometrial cancer?
3 Answers available
Would you consider offering immunotherapy +/- olaparib to a patient with early-stage endometrial carcinoma for whom you are recommending adjuvant chemotherapy based on improved outcomes seen in RUBY/DUO-E/NRG-GY018?
If yes, would you apply this broadly or reserve the addition of IO to chemotherapy for patients with high-risk histologies (e.g., carcinosarcoma) or o...
2 Answers available
In a patient with HER2+ advanced endometrial cancer, do you include IO(+/- olaparib) in their treatment regimen, or only trastuzumab in addition to carboplatin/paclitaxel?
Does your decision depend on MMR status? Would you use the same approach for neoadjuvant treatment?In light of relevant trials including RUBY, GY018, ...
3 Answers available
Would you recommend adjuvant chemo+IO +/- olaparib for patients with occult stage III disease identified after staging surgery with no measurable residual disease?
DUO-E, GY-018, and RUBY included patients with stage III and IV endometrial cancer WITH measurable disease.Would your decision change based on the mis...
4 Answers available
For patients with advanced endometrial cancer, are the improved outcomes in PFS from DUO-E/RUBY/NRG-GY018 sufficient to move immunotherapy to the frontline for all presuming FDA approval?
Are there patients for whom you would still reserve IO for salvage/recurrent setting (eg IO + lenvatinib)? Would you base this on MMR status or other ...
2 Answers available
How do you approach and manage anorexia and appetite loss in people with advanced cancer?
How do you counsel patients and caregivers? Do you prescribe medications (''appetite stimulants'') with the goal to improve appetite even if they do n...
4 Answers available
Do you follow GOG, ASTRO, or PORTEC recommendations for adjuvant therapy in stage I endometrial cancer patients?
What would you recommend for a patient in their 60s with stage IB grade 1 endometrial cancer without LVSI? How would this differ for a patient with st...
6 Answers available
Despite the paucity of strong data showing benefit of chemotherapy + radiotherapy in patients with stage I-II high risk histology endometrial cancer, if you recommend treatment with both modalities, how do you determine treatment schedule?
Do you proceed with sequential, concurrent, or sandwich treatment?
4 Answers available
What are your top takeaways from SGO 2023?
7 Answers available
Would you recommend PARP inhibitor maintenance for a patient with HR-proficient ovarian cancer with no targetable mutation, but with a favorable KELIM score and a significant clinical, radiographic, and serological response to platinum-based chemotherapy?
1 Answer available
After seeing results from GOG238, is there a subset of patients that might still benefit from chemoradiation for centrally recurrent endometrial cancer?
For example, do you think young patients might potentially benefit from the addition of cisplatin, knowing the average age in this study was 65.
1 Answer available
Would you treat endometrioid adenocarcinoma arising from an endometriosis lesion in a patient with prior hyst/BSO like an ovarian or endometrial primary?
Example: in a patient with a non-resectable pelvic mass involving the vagina but without evidence of distant disease, would you favor pelvic RT (as on...
3 Answers available
What is your approach to cancer patients who inquire about alternative or complementary treatments?
8 Answers available
Will you be changing your management of locally advanced cervical cancer based on the results of the recently published INTERLACE trial?
3 Answers available
What is your strategy for breakthrough chemotherapy induced N&V in patients receiving highly emetogenic chemotherapy and already received a NK-1 antagonist, 5-HT3 antagonist, dexamethasone, and olanzapine?
3 Answers available
When do you expect the 2023 FIGO staging for endometrial cancer to become adopted clinically in the US?
How will you translate treatment recommendations from older studies to the new staging system?
3 Answers available
In patients with advanced endometrial cancer who you plan to treat with chemotherapy + immunotherapy (per GY018 or RUBY), how and when do you utilize adjuvant EBRT and/or brachytherapy?
Does the presence of parametrial or cervical involvement impact your decision? How do you sequence treatment modalities?
3 Answers available
How would you manage a Stage IB endometrioid endometrial cancer, status post staging surgery, with a rapid vaginal recurrence <1 month post operatively?
This case involves an impressive ‘high volume’ vaginal recurrence and patient was not originally planned for adjuvant therapy. Concerned t...
2 Answers available
When the initial diagnosis of stage I uterine leiomyosarcoma is made via a non-intact resection such as a myomectomy or supracervical hysterectomy, what factors, if any, might push you to consider adjuvant chemotherapy after completion surgery?
1 Answer available
When treating stage IVB cervical cancer with both systemic chemotherapy and local pelvic radiation therapy, do you incorporate the use of bevacizumab as in GOG 240?
Consider treatment of stage IVB cervical cancer with systemic therapy and local pelvic radiation therapy as in Perkins et al., PMID 31810653.
2 Answers available
In the absence of a cohesive workflow guiding the use of PARPi in ovarian cancer since the 2022 FDA approval withdrawals, what is your general approach to PARPi usage in the front-line and recurrent setting?
1 Answer available
How do you treat cervical cancer with an ovarian metastasis?
Considering this is stage IV disease, do your recommendations for definitive or adjuvant treatment (after surgery) change?
2 Answers available
Based on the data from GY018 and RUBY, do you offer immunotherapy in addition to carboplatin/paclitaxel first line to all patients with advanced endometrial cancer who qualify or only to those whose tumors are MMR protein deficient?
2 Answers available
Would you recommend adjuvant chemotherapy to a patient who has stage IB grade 1 endometrioid endometrial cancer with isolated tumor cells in two pelvic lymph nodes and extensive LVSI?
1 Answer available
Is there still a role of brachytherapy in uterine cancer if intensity-modulated radiation therapy is available?
1 Answer available
Is it safe to treat checkpoint inhibitor-induced arthritis with methotrexate or biologics?
1 Answer available
How should molecular studies, in particular the presence of POLE or p53 mutations, be incorporated into the decision to treat an "intermediate risk" endometrial cancer patient with adjuvant therapy after hysterectomy?
Considering the ASTRO guidelines recommend against systemic therapy for patients with FIGO stage I-II endometrioid adenocarcinoma, would your recommen...
6 Answers available
Why do we use dexamethasone for CNS edema and prednisone for pneumonitis?
Is this an artifact of what agent prior clinical trials used or something to do with the mechanism of action (i.e., less mineralocorticoid effect of d...
1 Answer available
What is the optimal approach for a younger female with borderline resectable cervix cancer who may need adjuvant radiation, in light of a medical history significant for ulcerative colitis?
MRI pelvis shows a 3.5 cm primary that appears infiltrative and without clear parametrial extension on MRI. Staging PET negative.  Is there any ...
4 Answers available
What are your top takeaways in Gynecologic Cancers from ASCO 2023?
4 Answers available
How long would you continue second line maintenance PARP inhibitor in a patient with recurrent stage IV BRCA+ ovarian cancer who had CR and remains NED?
Do you extrapolate from first line maintenance studies for duration of therapy?
6 Answers available
With immunotherapy now often being used in the first-line setting for advanced endometrial cancer, what is the role of immunotherapy in the second-line?
Does the patient's MMR status affect your opinions? What is/are your current preferred second-line regimen(s)? 
1 Answer available
Given patients with substantial LVSI experience a pelvic recurrence rate of ~25%, how do you counsel patients with stage IA endometrioid endometrial cancer with LVSI regarding the relative risks/benefits of EBRT versus VBT alone?
Please comment on toxicity profiles and the insufficient evidence regarding overall survival.
5 Answers available
For patients on immune checkpoint inhibitors presenting with chest pain, dyspnea, fatigue, and troponin elevation, would you recommend early initiation of high dose steroids for empiric treatment of ICI myocarditis while pursuing workup with coronary angiogram, echocardiogram, and/or cardiac MRI, or wait until alternative etiologies have been ruled out?
2 Answers available
Do you offer PARP inhibitor maintenance retreatment of platinum-sensitive, relapsed, high grade serous ovarian cancer in patients who had a complete response to their most recent platinum-based chemo?
Front-line PARP inhibitor maintenance therapy discontinued without progression.
5 Answers available
How should PARP inhibitors be incorporated into clinical practice in later line/maintenance of platinum-sensitive ovarian cancer for PARP inhibitor-naïve patients?
Considering updated trials, such as final OS data from NOVA, and recent society guideline updates?
4 Answers available
What outcome data do you view as most impactful to make treatment decisions regarding the use of PARP inhibitors in later line or recurrent ovarian cancer?
Given the crossover that occurred in the various clinical trials and the potential for prolonged disease duration, how do you integrate OS, PFS, treat...
1 Answer available
Given more restrictions on later line PARP inhibitor use for patients by BRCA status, would you consider repeat biopsy with somatic testing to identify candidates for second line maintenance therapy following platinum treatment for a patient who is gBRCAwt?
Does your approach change depending on the patients initial somatic BRCA status?
2 Answers available
What are best practices for oncologists during the national platinum shortage?
Please specify how your institution is allocating resources now or will be soon.
13 Answers available
What is your surveillance approach for outpatient monitoring of ICI myocarditis?
(i.e. frequency of serial BNP, troponin, cMRI)
2 Answers available
Given recent studies investigating ICI myocarditis biomarkers such as Temra CD8+ cells, is there now a growing selection of clinical biomarkers, besides BNP and troponin, being measured routinely in ICI myocarditis cases? 
2 Answers available
When would you consider tapering glucocorticoids in a patient with ICI-associated myocarditis?
2 Answers available
What is your preferred first line systemic treatment for recurrent, metastatic, low grade, ER/PR+ pMMR endometrioid endometrial carcinoma?
3 Answers available
Would you consider chemoradiation + chemotherapy as in PORTEC-3 regimen for p53 mutated stage IA endometrial cancer, though this trial did not include those with stage IA disease?
If you do not use the PORTEC-3 regimen for p53 mutated IA endometrial cancer, what specific protocol or combination of chemotherapy and radiation ther...
5 Answers available
What is your approach to the adjuvant treatment of early-stage mixed-histology endometrial cancer with a significant clear-cell component?
How do you take into account pathologic factors like %clear cell histology, myometrial invasion, and LVSI?  
3 Answers available
What is your response to the question, "Is this terminal?"
How do you "have the talk" in a way that is straightforward without emotionally crushing the patient?
8 Answers available
How do you approach adjuvant treatment for node positive high grade gastric type endocervical adenocarcinoma following radical hysterectomy?
When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation?
1 Answer available
What is your approach for treating locally-advanced gastric-type adenocarcinoma of the cervix?
When would you use 5-fluorouracil instead of, or in addition to, cisplatin during chemoradiation? When, if ever, would you offer adjuvant hysterectomy...
5 Answers available
If blood counts are being checked during concurrent chemoradiation, is there a number at which point you would recommend a radiation treatment break?
For example, concerning throbocytopenia or neutropenia during anal cancer treatment with concurrent mitomycin/5FU, or other pelvic malignancies treate...
3 Answers available
When, if ever, would you consider deep venous thrombosis prophylaxis for patients with advanced epithelial ovarian cancer undergoing neoadjuvant chemotherapy?
In your practice, what is the proportion of patients receiving neoadjuvant chemotherapy who are diagnosed with VTE? Does this differ from patients rec...
2 Answers available
How would you treat a recurrent endometrial cancer at the vaginal cuff that was initially FIGO 1A with no adj treatment, in a patient with actively treated scleroderma?
3 Answers available
How would you approach the adjuvant treatment of a stage IVA adenosarcoma of the ovary?
Would your systemic therapy choice be more similar to treatment of ovarian carcinoma or soft tissue sarcoma?
1 Answer available
What is your approach to the adjuvant treatment for stage IA grade 2 endometrioid adenocarcinoma without LVSI whose molecular classification is p53 abnormal (MMR intact, POLE wild type)?
How does your approach differ for patients under age 60, between 60-70, and over age 70?
1 Answer available
What is your treatment approach for a pediatric patient with uterine embryonal rhabdomyosarcoma found after removal of a prolapsing uterine mass, with no evidence of distant metastasis on imaging?
1 Answer available
How would you treat an isolated para-aortic lymph node endometrial cancer recurrence following a prolonged disease free interval previously treated with surgery, chemotherapy, and radiation therapy, if it is located outside of the previously irradiated field?
How does histology and/or molecular testing change your approach? How does the length of the disease free interval change your approach?
1 Answer available
How do you approach hormone replacement therapy for premenopausal patients following pelvic radiation therapy?
How is your approach different from or similar to those who undergo surgical menopause? 
1 Answer available
How do you approach treatment for ovarian carcinosarcoma that has progressed during adjuvant carboplatin, paclitaxel, and bevacizumab following optimal tumor reductive surgery?
How would you approach the treatment if the tumor is PDL1+?
1 Answer available
What is your approach to first line systemic treatment for low risk gestational trophoblastic neoplasia?
Is there an optimal chemotherapy regimen that optimizes cure rates while minimizing side effects?
2 Answers available
Would you give checkpoint inhibitor therapy to a cancer patient with known dermatomyositis given the association of checkpoint inhibitor associated myocarditis, myasthenia gravis, and myositis?
6 Answers available
What is your approach to first line systemic therapy in metastatic PD-L1 positive cervical cancer?
Do you include pembrolizumab with platinum-taxane + bevacizumab or reserve it as a second line option?
2 Answers available
How would you approach the primary treatment of a rapidly growing uterine carcinosarcoma with local extension through the anterior abdominal wall?
If considering systemic therapy, would you consider standard chemotherapy or use biomarker-directed therapy (e.g., imatinib if ckit+, larotrectinib/en...
2 Answers available
How do you approach adjuvant therapy for patients with advanced ovarian cancer who undergo interval debulking surgery following six cycles of neoadjuvant chemotherapy?
How does your approach vary based on residual disease left at the time of surgery? Please specify your approach for the amount of residual disease at ...
2 Answers available
Do you initiate management of new onset diabetes in a patient on immunotherapy or refer immediately to endocrinology given the risk of rapid worsening?
1 Answer available
How do you discern whether elevated liver enzymes are from immunotherapy versus chemotherapy when a patient is on combination chemo/immunotherapy?
2 Answers available
How does your approach to low-risk gestational trophoblastic neoplasia differ for patients whose hCG levels plateau following initial single agent systemic therapy vs those who have a good initial response and then plateau?
1 Answer available
How do you approach systemic treatment for endometrial endometrioid adenocarcinoma with neuroendocrine differentiation?
In what situations would you use a neuroendocrine chemotherapy regimen over carboplatin+paclitaxel?
2 Answers available
What is your approach to adjuvant treatment for stage IA small cell carcinoma of the ovary, hypercalcemic type, after fertility sparing surgical staging?
1 Answer available
How do you manage steroid-refractory immune checkpoint inhibitor induced pneumonitis?
4 Answers available
Do you offer patients with advanced endometrial cancer lower starting doses of lenvatinib when used in combination with pembrolizumab given high adverse event rates with 20 mg daily?
Is there a role for using pembrolizumab alone in microsatellite stable endometrial cancer if patients are unable to tolerate lenvatinib?
3 Answers available
What are real world exclusion criteria for the use of lenvatinib + pembrolizumab for advanced endometrial cancer?
Are there specific clinical or social scenarios that would preclude the use of this treatment?
2 Answers available
Is there a difference in survival or disease response between patients with recurrence free interval ≥1 vs <1 year from platinum-based cytotoxic therapy who are treated with pembrolizumab + lenvatinib?
In the KEYNOTE-775 study, what was the proportion of patients who had a recurrence free interval ≥1 year from platinum-based cytotoxic chemotherapy...
1 Answer available
Are there any data that suggest superiority of lenvatinib + pembrolizumab vs platinum-based cytotoxic chemotherapy for advanced or recurrent endometrial cancer?
Are there any planned trials to compare lenvatinib + pembrolizumab and platinum-based cytotoxic chemotherapy for advanced or recurrent endometrial can...
1 Answer available
How do you approach adjuvant chemotherapy for high risk/advanced endometrial cancer patients?
Does your approach to the number of cycles vary based on plan to include radiation therapy or presence of certain histopathologic features?
1 Answer available
Is there a difference in the incidence of serious immune-related adverse events with the lenvatinib + pembrolizumab combination vs pembrolizumab alone in endometrial cancer?
Anecdotally, I have seen more serious IRAEs in patients I'm treating with this regimen than anticipated. Is there higher risk with this drug combinati...
3 Answers available
Can you continue checkpoint inhibitor therapy in the setting of severe cutaneous irAE while concurrently treating the cutaneous reaction?
2 Answers available
How would you manage a bulky, locally advanced endometrial cancer with extensive parametrial involvement in a patient inoperable due to medical comorbidities?
3 Answers available
When, if ever, would you consider lenvatinib + pembrolizumab as first line therapy for patients with stage IV microsatellite stable endometrial cancer?
Are there certain patient or disease related factors that would lead you to incorporate lenvatinib + pembrolizumab earlier?
1 Answer available
Do you routinely use mannitol to prevent cisplatin-induced nephrotoxicity?
If so, do you use it for all patients or only cisplatin doses >= 70 mg/m2? What dose of mannitol do you use?
4 Answers available
What is optimal therapy for a 5 year delayed recurrence of uterine cancer, rendered NED by solitary pulmonary metastasis resection?
And if the tumor is MSI-H, does that alter your thoughts?
3 Answers available
What is your institutional approach to a restrictive “neutropenic diet”?
3 Answers available
What is your strategy to help prevent paclitaxel-related neuropathy?
Do you prophylactically start all patients on B12, B-complex, and/or omega-3? If so, what dose? What about ice mittens and booties?
3 Answers available
Would you consider a PARP inhibitor in the treatment of a PARP inhibitor naïve platinum resistant recurrent ovarian cancer with LOH/HRD?
1 Answer available
In the setting of platinum resistant ovarian cancer, do you consider repeat use of bevacizumab with subsequent lines of chemotherapy following prior treatment with chemotherapy + bevacizumab with bevacizumab maintenance?
Considering the treatment of platinum resistant ovarian cancer as done in the AURELIA trial (Pujade-Lauraine et al., PMID 24637997).
1 Answer available
What are your top takeaways in Gynecologic Cancers from ASCO 2022?
What were your “top 3” presentations/studies coming out of the meeting this year and how will it impact your own clinical practice? ...
2 Answers available
What is your preferred adjuvant chemotherapy regimen after a completely resected stage IIIB Granulosa Cell tumor of the ovary?
1 Answer available
Do you routinely check tumor genomics, including POLE status for new endometrial cancers?
How does the presence of specific mutations affect your adjuvant treatment planning or patient counseling? Given POLE mutation status can currently o...
1 Answer available
How has the virtual aspect of tumor boards impacted their educational quality in the Covid-19 era?
1 Answer available
If a patient with HER2+ uterine serous carcinoma recurs while on maintenance trastuzumab, would you continue trastuzumab with second line chemotherapy?
Given data from metastatic breast cancer trials that show benefit with continuing trastuzumab despite progression.
2 Answers available
How do you manage insomnia in cancer patients that is refractory to traditional sleep aides?
In patients who continue to have insomnia despite diphenhydramine, benzos, and trazodone, are there other evidence based treatments that are helpful?
4 Answers available
How do you proceed after a patient has a partial response following 6 cycles of cisplatin + paclitaxel + bevacizumab +/- pembrolizumab for metastatic SCC of the cervix?
Assuming minimal toxicities except fatigue from long, recurrent infusions.
2 Answers available
How do you manage real-time release of pathology and radiology results to oncology patients following enaction of the CURES act?
1 Answer available
How do you determine duration of anticoagulation for an ovarian vein thrombosis following a provoking event?
1 Answer available
Would you modify standard WPRT+brachy radiation for cervical SCC s/p negative nodal staging but aborted hysterectomy due to previously undetected superficial vaginal disease?
1 Answer available
How do you manage patients with chemotherapy-induced paronychia?
1 Answer available
In patients with recurrent MSI-H endometrial cancer on immunotherapy with pembrolizumab, when do you discontinue therapy?
Do you stop therapy at 2 years or continue until progression of disease?
1 Answer available
Are there best practices or data regarding the use of open notes among oncology patients?
What is the impact among patients and providers? Has your documentation been adjusted now that patients can readily review?
2 Answers available
What is your adjuvant therapy for node positive, low grade endometrioid endometrial adenocarcinoma?
3 Answers available
How do you integrate ophthalmic exam and surveillance into routine visits for cervical cancer patients receiving tisotumab vedotin?
2 Answers available
Do you treat an endometrial cancer that is microsatellite-stable but has a high TMB after progressing on platinum-based therapy with pembrolizumab?
2 Answers available
What features help distinguish thyroid myopathy from immune checkpoint inhibitor-associated myopathy?
1 Answer available
How do you manage the wide array of emotions like anger and disappointment patients may have when they first learn of an incurable relapse of an early stage cancer?
How do you maintain a trusting relationship with your patients when this relapse occurs?
1 Answer available
What chemotherapy would you consider to treat platinum resistant high grade serous ovarian cancer in patients with a low grade MDS from prior platinum/PARPi?
Assuming low risk of progression to AML and eligible for low-risk chemotherapies per hematologic/oncology.
1 Answer available
When a patient with a preexisting rheumatic disease and on immunotherapy begins to flare, how do you decide if this is an underlying rheumatic disease activity versus an immunotherapy related adverse event?
How do you decide if it may be safe to continue immunotherapy?
1 Answer available
How do you manage a screening pap smear result of HSIL and HPV16+ in a first trimester pregnancy?
2 Answers available
Does the presence of an ATM mutation in advanced stage ovarian cancer influence the decision to use Bev vs PARP inhibitor for maintenance?
2 Answers available
What adjuvant therapy do you recommend for early stage poorly differentiated small cell neuroendocrine carcinoma of the cervix after surgical resection?
2 Answers available
When do you transfuse cervical cancer patients undergoing chemoradiation?
Do you try to keep Hb> 10 or 12? Or somewhere in between? 
2 Answers available
What recommendations are you giving when patients ask about the best 'cancer diet' to be on?
Do you routinely recommend any dietary changes or is the evidence not convincing?
1 Answer available
When, if ever, would you recommend risk reducing BSO in patients with moderate penetrance breast cancer germline mutations?
Genes such as ATM, CHEK2, PALB2, RAD51C/D, BRIP1 seem to show some potential increased risk of ovarian cancer. Should these patients under prophylacti...
2 Answers available
How do you counsel premenopausal women with BRCA1 or BRCA2 mutations on the need for bilateral oopherectomy?
2 Answers available
Would concurrent endocrine therapy and PARPi maintenance be safe and appropriate after surgical treatment/adjuvant chemotherapy for a patient with BRCA1 mutated synchronous early stage HR+ breast CA and Stage IIA Fallopian tube carcinoma?
1 Answer available
What is your approach to the management of hot flashes in a patient who wants to use herbal medicine?
Do you allow patients with breast cancer on tamoxifen to use black cohosh?
2 Answers available
Would you add a PARP inhibitor to bevacizumab maintenance for a patient with a high grade serous ovarian cancer with a germline BRCA2 variant of unknown significance and negative somatic testing?
1 Answer available
In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?
2 Answers available
In women of childbearing age with NMDA encephalitis and normal pelvic imaging, is there a role for oophorectomy for possible microteratoma?
If not, how often do you repeat pelvic imaging?
1 Answer available
Do you recommend adjuvant treatment for nodal isolated tumor cells in an otherwise low-risk endometrial cancer?
1 Answer available
How would you approach a primary small cell carcinoma of the vagina in a patient with an intact uterus and cervix?
1 Answer available
How would you proceed for a patient with metastatic gastric-type adenocarcinoma, with vaginal and inguinofemoral disease only, who experiences complete response to her vaginal tumor but residual inguinal disease?
History of CDH1 mutation and prophylactic gastrectomy in 2017 - no other primary site found beyond vagina at diagnosis. Vaginal tumor completely resp...
2 Answers available
What strategies have you found to be most effective in engaging PCPs in a primary-care or shared-care model of survivorship for pediatric and AYA patients who will receive ongoing care in their communities away from their primary oncology treatment site?
In follow up to @Jacqueline Casillas presentation at ASCO 2021 regarding models of survivorship care delivery for AYA patients. 
1 Answer available
What is your approach to immunotherapy-related pancreatitis?
How do you manage the initial event, including length of steroid taper and the role of pancreatic enzyme monitoring? What is your experience of subse...
1 Answer available
In what scenario would you give consolidation chemotherapy after chemoradiation for stage 3 cervical cancer with a good response?
3 Answers available
Would you offer any adjuvant therapy for cervical cancer following total pelvic exenteration in the setting of a positive pelvic lymph node?
Previously received pelvic EBRT and intracavitary brachytherapy. IORT was administered to the node-positive side wall at the time of exenteration.
3 Answers available
How would you proceed after complete response to carboplatin/paclitaxel/bevacizumab in a patient who presented with distantly recurrent SCC of the cervix?
Initially treated with definitive chemoRT but recurred with distant mets. Completed 6 cycles carb/tax/bev with minimal toxicity. Excellent performance...
1 Answer available
What chemotherapy would you utilize for a metastatic dysgerminoma diagnosed in the second trimester of pregnancy?
1 Answer available
How would you manage a patient with history of locally advanced SCC of the cervix, treated with definitive chemoRT, found to have new lung lesions 6 months post treatment?
Lung is biopsy proven met cervix, SBRT is planned. 
2 Answers available
What would be your treatment approach for a patient with a new PET positive para-aortic node 3 months following completion of definitive chemoradiation for locally advanced cervical cancer?
Patient did not previously receive para-aortic radiation. Considering RT vs RT  + chemo vs chemo alone
1 Answer available
How do you manage cancer treatment-related cognitive change or "chemo brain?"
Are there any effective non-pharm or pharm interventions?
1 Answer available
How would you approach treatment for centrally recurrent cervical SCC with positive margins after excision that was not exenteration?
Recurrence was 2cm and PET confirmed local. Excision with positive margins. Current plan for salvage whole pelvic RT and vaginal cuff brachytherapy +/...
3 Answers available
How would you treat an advanced stage small-cell carcinoma of the ovary, hypercalcemic type? (SCCOHT)?
s/p optimal debulking. If this was an early-stage cancer would it change your adjuvant therapy recommendations?
1 Answer available
How would you adjust therapy for a patient with high risk, stage III choriocarcinoma (lung mets) in the context of renal insufficiency (Cr 3.8)?
1 Answer available
What chemotherapy regimen would you utilize for a metastatic, poorly differentiated carcinoma of the cervix with neuroendocrine features?
If confirmed neuroendocrine and PD-L1 pending, how would you treat?
3 Answers available
How would you manage a patient with history of stage IIIC HGSOC after secondary cytoreduction of isolated inguinal node recurrence 12 years after primary treatment?
Recurrence picked up incidentally on CT. No germ line mutations, somatic tumor testing of node resulted negative. PET confirmed isolated recurrence
1 Answer available
What is your strategy to prevent and treat constipation in patients initiating or receiving opioids?
What non-pharmacological interventions do you recommend? Do you routinely prescribe prophylactic laxatives to patients initiating opioids? How do you ...
3 Answers available
Would you recommend PARP inhibitor maintenance for a BRCA wild-type, HRD+ advanced ovarian cancer?
2 Answers available
After an optimal tertiary cytoreduction for recurrent granulosa cell tumor previously treated with BEP and hormonal therapy, would you recommend systemic chemotherapy?
Initial diagnosis was 15+ years ago
2 Answers available
Is there any role for PARPi maintenance in BRCA-/HRD- patients after response to front line chemotherapy +/- bevacizumab?
2 Answers available
What factors impact your decision to include bevacizumab with primary chemotherapy for patients with BRCA+ or HRD+ ovarian cancer?
Does your practice vary based on risk status (low vs high risk) or specific mutation status (BRCA+ vs HRD+) given PAOLA subset analyses? 
4 Answers available
Are there circumstances where you would recommend every 6 week dosing schedule for pembrolizumab monotherapy?
I am considering every 6 week pembrolizumab dosing in patients >70 years old in whom I want to reduce clinic visits for, especially in the context ...
3 Answers available
What is your current practice for obtaining mutation status for a patient with newly diagnosed ovarian cancer?
What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?
3 Answers available
How would you treat/counsel a patient with Stage IB3 SCC of the cervix who is 18 weeks pregnant and desires to maintain pregnancy?
1 Answer available
Is there a role for reassessing somatic mutation status at relapse in patients with epithelial ovarian cancer?
If yes, what type of testing platform would you use?
2 Answers available
When would you continue bevacizumab versus using PARPi alone for maintenance therapy in BRCA+ or HRD+ ovarian cancer after response to primary platinum + bevacizumab?
Are there clinical factors which help stratify? Does your practice vary based on mutation status (BRCA+ vs HRD+?)
3 Answers available
Which PARP inhibitor do you recommend for maintenance therapy in BRCA+ ovarian cancer after primary chemotherapy and why?
How do the 5 year results of SOLO-1 at ESMO 2020 impact your recommendations?
3 Answers available
How do you logistically give sandwich chemotherapy and whole pelvis radiation treatment in advanced endometrial cancer?
How many cycles do you prefer before and after? How long do you tend to wait before starting radiation after initial chemo and after radiation to resu...
1 Answer available
How do you advise patients on duration of first line maintenance PARPi and the potential risk of MDS or AML?
Is MDS/AML risk increased with longer duration of therapy? Does your approach differ for patients who are BRCA+/HRD vs wild type/HRP?
2 Answers available
What are the current official guidelines regarding COVID-19 vaccination for patients with cancer or for hematologic conditions?
2 Answers available
When might you recommend adjuvant chemotherapy for fully staged/resected stage IA clear cell ovarian carcinoma?
2 Answers available
How would you treat metastatic squamous cell carcinoma arising from a mature cystic ovarian teratoma?
1 Answer available
How do you counsel patients who are candidates for a clinical trial regarding their options?
Specifically, are there strategies you use to 1) empower patients to participate in decision-making and 2) reassure patients who may be skeptical?
2 Answers available
How do you perform geriatric assessment for cancer patients?
Do you use specific tools or take into account certain factors when considering treatment options for older adults?
1 Answer available
If a patient with recurrent endometrial cancer experiences minimal or slow disease progression on pembrolizumab or pembro/lenvatinib, would you consider continuing or would you change agents?
Patient has tolerated combination therapy well to date.
1 Answer available
How would you approach diagnosis of residual ovarian tissue in a patient with ER positive breast cancer, history of BSO, and a rising estradiol level on tamoxifen?
1 Answer available
Would you consider retrying a platinum based chemotherapy agent in a platinum resistant ovarian cancer patient?
3 Answers available
In what scenario would you prefer weekly vs every 3 week carboplatin/paclitaxel for high grade serous ovarian cancer?
3 Answers available
How are you counseling HR-proficient ovarian cancer patients about front line PARP inhibitor maintenance?
Given recent approval of niraparib (Zejula) for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or prima...
2 Answers available
How would you counsel a patient regarding possibility of ovarian preservation at time of surgery for malignant mesothelioma initially discovered in a myomectomy specimen and involving peritoneal surfaces?
Patient is 34yo and G0 referred from surgical oncology. Laparoscopic specimens of myoma and what appeared to be adhesions were significant for maligna...
1 Answer available
How does positive p53 staining influence your recommendation for adjuvant therapy in comprehensively staged early (stage IA or IB), grade 2, endometrioid endometrial cancers? 
If patient meets high intermediate risk criteria, would you consider chemotherapy in addition to radiation?
1 Answer available
Would the presence of multifocal LVSI change your adjuvant treatment recommendation for a surgically staged IA dedifferentiated endometrial carcinoma?
Does not technically meet high intermediate risk criteria.
2 Answers available
In a patient with high-risk gestational trophoblastic neoplasia, how would you approach treatment of recurrence at 6 months post EMA-CO?
Tolerated first line, however now with rising Beta-HCG, new mass in uterus, and pulmonary metastases.
1 Answer available
How do you incorporate surveillance imaging for patients with ovarian cancer on maintenance therapy?
Does your strategy differ if the patient is on maintenance PARP inhibitor, bevacizumab, both, or neither? 
1 Answer available
Do you re-test patients who test positive for COVID-19 during or prior to starting cancer treatment?
There are mixed recommendations about re-testing vs simply waiting for a quarantine period prior to resuming therapy. 
2 Answers available
Would you consider HRT after BSO in a pre-menopausal gBRCA2+ patient who has no intention of ever having prophylactic bilateral mastectomies and who declines chemoprophylaxis?
2 Answers available
How would you manage a recurrent uterine leiomyosarcoma, now status post secondary cytoreduction, with no gross residual disease?
Would you consider adjuvant chemotherapy, radiation therapy, hormone therapy, or surveillance?
1 Answer available
Do you routinely prophylactically anticoagulate patients undergoing systemic chemotherapy outside of the perioperative period?
1 Answer available
How would you manage a young woman with vulvar langerhans cell histiocytosis and positive margins after wide local excision?
1 Answer available
Would development of a rectovaginal fistula mid-treatment with second line pembrolizumab/lenvatinib for endometrial cancer cause you to change regimens, eliminate lenvatinib, or continue current therapy?
The patient has a history of pelvic radiation and progressed through first line carboplatin/taxol. She has had a partial response to pembro/lenvatinib...
1 Answer available
How do you sequence chemotherapy with radiotherapy for advanced endometrial cancer?
4 Answers available
Are you offering PARP inhibitor alone or both PARP inhibitor and bevacizumab maintenance for HRD+ ovarian cancer patients after upfront treatment?
Based on recent PAOLA-1
1 Answer available
Are there scenarios that new visits/consults with patients can be done virtually amidst the COVID-19 outbreak?
6 Answers available
What adjuvant therapy would you offer a patient with Stage II uterine serous carcinoma without lymph node sampling?
3 Answers available
How do you approach the pharmacologic management of cancer-related fatigue?
After optimizing symptoms and reversible factors, and attempting cognitive-behavioral interventions and exercise, do you recommend pharmacologic agent...
2 Answers available
Would you offer adjuvant therapy following successful resection of a solitary lung recurrence of leiomyosarcoma if no other evidence of recurrent disease on PET CT?
1 Answer available
What starting dose of lenvatinib are you ultilizing in recurrent endometrial cancer patients initiating lenvatinib/pembro?
1 Answer available
Would you recommend systemic therapy in a patient with a history of Stage III high grade serous endometrial cancer s/p resection of a solitary pulmonary metastasis after a long disease free interval?
Does residual grade 1-2 neuropathy from Taxol/ carbo 10 years ago affect your recommendation?
2 Answers available
What upfront maintenance therapy would you recommend for a BRCA negative, advanced epithelial ovarian cancer patient after completing adjuvant carboplatin, paclitaxel, bevacizumab?
1 Answer available
Do you recommend concurrent chemotherapy with XRT for inoperable patients with stage I-II high-risk endometrial carcinoma?
Ie for patients who are inoperable due to comorbidities?
2 Answers available
Would you recommend maintenance therapy with a PARP inhibitor for BRCA+ patients with advanced uterine serous cancer?
Since no data exists or is pending, and the two disease processes are similar, should we consider PARP inhibition in this setting? This is assumi...
1 Answer available
How do you approach the decision of whether and when to initiate therapy in patients who remain COVID-19 positive >2 weeks after infection but are asymptomatic from the virus?
E.g. a patient with progression of their primary cancer but still is testing COVID19+ over a month after infection?
5 Answers available
How do you talk to patients about clinical trials?
I care deeply about clinical trials but have always struggled on how to approach this topic. I would really appreciate tips from those of you who have...
5 Answers available
Is there a Mednet app?
2 Answers available
When, if ever, would you recommend hysterectomy after chemoradiation for patients with locally advanced cervical cancer?
This has been a common practice in the community. Is there a benefit for certain patients?
2 Answers available
How do you manage taxane acute pain syndrome (TAPS)?
Can it be prevented? How do you evaluate patients? What non-pharmacologic or pharmacologic interventions do you use for treatment?
1 Answer available
Do you routinely prescribe anticoagulation for patients on active chemotherapy?
1 Answer available
How do you decide the right time to transition to hospice?
Obviously, patient and caregiver preferences are paramount. But, what factors do you consider? Does expanded hospice (e.g., Medicare Care Choices) inf...
4 Answers available
Would you give a PARP inhibitor, and at what dose, to a patient with end-stage renal disease on hemodialysis after completion of 6 cycles of carboplatin and paclitaxel for advanced ovarian cancer?
1 Answer available
Should our selection for neoadjuvant chemotherapy in ovarian cancer patients change in light of COVID-19?
1 Answer available
Are maintenance therapies for ovarian cancer being held at your institution due to COVID-19?
2 Answers available
Are you altering your use of immune checkpoint inhibitors given the risk of immune-related pneumonitis and the COVID-19 outbreak?
2 Answers available
How should you manage a COVID-19 infected/suspected patient who is receiving chemotherapy and cannot interrupt or delay their cancer treatment?
2 Answers available
How should you manage a coronavirus infected/suspected patient who is receiving radiotherapy and cannot interrupt or delay their cancer treatment?
How would you approach a patient who is receiving chemoRT but has confirmed COVID-19 with minor symptoms, as breaking treatment for 2 weeks quarantine...
7 Answers available
What are the current official guidelines regarding managing patients during COVID-19?
3 Answers available
Should I wear gloves during a routine physical exam on an asymptomatic patient with no risk factors for COVID-19?
1 Answer available
What measures should we take regarding routine follow-up visits for well patients in surveillance during the coronavirus pandemic?
When a physical exam is important and telehealth is not a good option, should we be proactive and reschedule or should we continue to see them as sche...
2 Answers available
In a patient metastatic recurrent endometrioid endometrial cancer who has a mixed response to carboplatin and paclitaxel, what is your next choice of therapy?
 No adjuvant treatment was given upfront
1 Answer available
Is your approach to managing immune related adverse events altered at all in light of COVID-19?
2 Answers available
What adjuvant chemotherapy is preferred in primary ovarian mucinous adenocarcinoma of intestinal type?
2 Answers available
How do you explain progression free survival to patients?
5 Answers available
Before re-challenging a patient with ICI after grade 1-2 pneumonitis, do you re-image to confirm resolution of pneumonitis?
1 Answer available
Do you routinely offer PARP inhibitor maintenance therapy to germline BRCA1/2+, FIGO stage II serous ovarian carcinoma patients after adjuvant chemotherapy?
SOLO1 trial studied stage 3/4 patients.
1 Answer available
What is optimal timing or sequencing of therapy for patients with synchronous locally advanced triple negative breast cancer and ovarian cancer with peritoneal carcinomatosis?
2 Answers available
How would you manage a patient with synchronous breast and ovarian cancer, s/p neoadjuvant chemotherapy and surgery for ER+/HER2- breast cancer and found to have an ER+ ovarian cancer nodal metastases at TAH/BSO?
RP node with treatment related changes and surgical specimen from TAH/BSO no other foci of malignancy found. 
1 Answer available
Do you recommend frontline bevacizumab with carbo/taxol in patients with advanced epithelial ovarian and BRCA mutation who will be receiving olaparib maintenance?
1 Answer available
In light of GOG-252, are there any situations where IP chemotherapy would be preferable following debulking of advanced epithelial ovarian cancer?
1 Answer available
When do you choose dose-dense chemotherapy v. q3 week therapy in advanced epithelial ovarian cancer?
1 Answer available
What is your preferred sequence of chemotherapy regimens after patients with metastatic endometrial cancer develop resistance to carboplatin + paclitaxel?
1 Answer available
How do you choose 1st line therapy for recurrent cervical cancer?
Would you be more or less likely to use a cisplatin-containing regimen if a patient had previously responded to chemoradiation with concurrent cisplat...
1 Answer available
How do you determine which systemic therapy to recommend in the 2nd line setting for metastatic, PD-L1 NEGATIVE cervical cancer?
1 Answer available
Would you recommend EBRT/brachythrapy for any patients with stage III- IV uterine ca in light of GOG-258 data?
https://www.nejm.org/doi/full/10.1056/NEJMoa1813181
1 Answer available
Do you consider tumor mutation burden as a possible biomarker for response to immune checkpoint therapy in the second line setting for cervical cancer?
1 Answer available
Is pembrolizumab considered standard of care in the 2nd line treatment of recurrent cervical cancer?
Does the phase II KN-158 provide sufficient evidence to change management?
1 Answer available
Would you recommend 1st line pembrolizumab for PD-L1 positive recurrent/metastatic cervical cancer patient who is not a candidate for or refuses chemotherapy?
1 Answer available
When do you recommend PD-L1 testing for patients with recurrent cervical cancer?
Should this be done at the time of recurrence or after failure of 1st line therapy for recurrence?
1 Answer available
How do you decide on adjuvant therapy in a patient with a Stage IA uterine carcinosarcoma without any myometrial invasion?
The NCCN recommends either systemic therapy + brachytherapy or pelvic RT + brachy or brachy alone or observation. How do you decide among these option...
1 Answer available
Do you recommend stopping olaratumab in patients receiving doxorubicin/olaratumab for treatment of advanced sarcoma?
Given the recent press release regarding the update on the phase 3 soft tissue sarcoma study of LARTRUVO (olaratumab) showing no benefit to the combin...
1 Answer available
For a patient with carcinosarcoma of the uterus and an allergic reaction to paclitaxel, would you have any reservations about using docetaxel instead?
1 Answer available
Now that there are three FDA-approved PARP inhibitors for use in ovarian cancer (niraparib, rucaparib, olaparib), how do you decide which one to use?
2 Answers available
Should olaparib maintenance therapy be recommended in patients with BRCA-positive, advanced ovarian cancer after first line platinum-based chemotherapy?
Should this be the new standard of care based on the results from the recently published SOLO-1 trial?
1 Answer available
When do you refer a patient with metastatic ovarian cancer for upfront debulking v. neoadjuvant chemotherapy?
1 Answer available
Should women with adequately debulked ovarian cancer receive bevacizumab with chemotherapy in the adjuvant setting?
3 Answers available
How do you determine the choice of therapy for platinum resistant ovarian cancer in healthy, good performance status patients?
Two new phase 2 studies this year with apatinib/oral etoposide (AEROC) and sorafenib/topotecan (TRIAS) were released, and NCCN also lists many single ...
3 Answers available
Do you recommend bevacizumab in platinum sensitive recurrences of epithelial ovarian cancer?
Or do you wait for platinum resistance?
1 Answer available
In patients with recurrent advanced ovarian carcinoma and a hypersensitivity reaction to platinum, do you prefer a desensitization protocol to maximize response or switching to a non-platinum regimen?
1 Answer available
Is it safe and/or necessary to combine osimertinib and carboplatin/paclixel for a patient with stage IV EGFR mutated NSCLC and advanced ovarian carcinoma?
Certainly ovarian cancer will respond to carboplatin and paclitaxel and it sounds like a reasonable chemotherapy to give to a stage IV NSCLC, however ...
1 Answer available
What is your approach to an optimally debulked patient with Stage Ia FIGO gr 3 serous carcinoma of the ovary?
Is it reasonable to use single agent carboplatin for elderly patients?
2 Answers available
Is further workup and management required for an incidentally found small focus of neuroendocrine tumor of the endometrium?
In a patient who underwent laparoscopy for endometriosis and was found to have a 1mm focus of neuroendocrine tumor, would you recommend further surger...
1 Answer available
What is the preferred second line agent for a woman with metastatic vulvar cancer who has progressed on carboplatin/paclitaxel?
She has metastatic disease beyond the pelvis (lungs).
2 Answers available
For a young patient with stage 4 endometrial cancer with an excellent response to anthracyclines, would you continue to give anthracyclines beyond the standard dosage cap if cardiac function remains normal by echocardiogram?
1 Answer available
How would you manage a patient with low-volume non-invasive endometrioid carcinoma that is found in both the endometrium and ovary (pN0)?
Would you approach this situation as synchronous primaries (eg. FIGO IA in both) or as a locally advanced endometrial cancer (FIGO IIIA)? What adjuva...
2 Answers available
Which chemotherapy regimen (if any) do you recommend for palliative concurrent chemoradiation for a symptomatic patient with metastatic cervical carcinoma and CKD stage 4 (GFR 15-29)?
1 Answer available
In what situations should chemotherapy be added to adjuvant radiation therapy in a resected vuvlar SCC?
Would you add chemotherapy if there was gross residual disease, pN+ and/or ECE?
2 Answers available
How would you treat small cell cancer of the cervix?
Can the classic indications for post-hysterectomy radiation (eg. "Sedlis" and "Peter's" criteria) be applied? Does the histology change radiation dose...
1 Answer available


Papers discussed in this category

Gynecol Oncol, 2019 Aug 16
Advanced communication: A critical component of high quality gynecologic cancer care: A Society of Gynecologic Oncology evidence based review and guide.
JAMA,
The care of the patient.
JAMA Netw Open, 2021 Apr 01
Red Blood Cell Transfusion Practices for Patients With Cervical Cancer Undergoing Radiotherapy.
Gynecologic oncology, 2010-03
The potential benefit of 6 vs. 3 cycles of chemotherapy in subsets of women with early-stage high-risk epithelial ovarian cancer: an exploratory analysis of a Gynecologic Oncology Group study.
The New England journal of medicine, 2019-06-13
Adjuvant Chemotherapy plus Radiation for Locally Advanced Endometrial Cancer.
Lancet Oncol., 2019 Jul 22
Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): patterns of recurrence and post-hoc survival analysis of a randomised phase 3 trial.
Gynecol Oncol, 2019 Sep
Defining the survival benefit of adjuvant pelvic radiotherapy and chemotherapy versus chemotherapy alone in stages III-IVA endometrial carcinoma.
Gynecologic oncology, 2004-04
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence.
American journal of obstetrics and gynecology, 2010-10
Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients.
Obstetrics and gynecology, 1988-01
Surgically treated, early-stage neuroendocrine small-cell cervical carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2014-11
Gynecologic Cancer InterGroup (GCIG) consensus review for small cell carcinoma of the cervix.
Gynecologic oncology, 2015-06
Impact of adjuvant chemotherapy with radiation for node-positive vulvar cancer: A National Cancer Data Base (NCDB) analysis.
The Lancet. Oncology, 2017-09
Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial.
Cancer, 1987-10-15
Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study.
Gynecologic oncology, 2015-09
Ovarian involvement in endometrioid adenocarcinoma of uterus.
Curr Oncol Rep,
Pathology of Neuroendocrine Tumours of the Female Genital Tract.
Adv Anat Pathol,
Assigning site of origin in metastatic neuroendocrine neoplasms: a clinically significant application of diagnostic immunohistochemistry.
Gynecologic oncology, 2014-11
Neoadjuvant radiotherapy with or without chemotherapy followed by extrafascial hysterectomy for locally advanced endometrial cancer clinically extending to the cervix or parametria.
N Engl J Med, 2016 Feb 25
Weekly vs. Every-3-Week Paclitaxel and Carboplatin for Ovarian Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-01
Randomized Trial of Intravenous Versus Intraperitoneal Chemotherapy Plus Bevacizumab in Advanced Ovarian Carcinoma: An NRG Oncology/Gynecologic Oncology Group Study.
The New England journal of medicine, 2011-12-29
Incorporation of bevacizumab in the primary treatment of ovarian cancer.
N Engl J Med, 2011 Dec 29
A phase 3 trial of bevacizumab in ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-09-10
Final Overall Survival of a Randomized Trial of Bevacizumab for Primary Treatment of Ovarian Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-06-10
OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer.
Lancet Oncol, 2017 Jun
Bevacizumab and paclitaxel-carboplatin chemotherapy and secondary cytoreduction in recurrent, platinum-sensitive ovarian cancer (NRG Oncology/Gynecologic Oncology Group study GOG-0213): a multicentre, open-label, randomised, phase 3 trial.
Lancet (London, England), 2017-10-28
Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial.
The New England journal of medicine, 2016-12-01
Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer.
The New England journal of medicine, 2012-04-12
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer.
J. Clin. Oncol.,
Mucinous epithelial ovarian cancer: a separate entity requiring specific treatment.
J Clin Oncol, 2014 May 1
Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial.
Int J Gynecol Cancer, 2018 Mar
An Outpatient, Dose-Intense, Intravenous Cisplatin and Oral Etoposide Regimen for the Treatment of Advanced, Platinum-Resistant Ovarian Cancer.
Br. J. Cancer,
Weekly cisplatin and daily oral etoposide is highly effective in platinum pretreated ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2015-02
Clinical response to antiestrogen therapy in platinum-resistant ovarian cancer patients and the role of tumor estrogen receptor expression status.
The New England journal of medicine, 2018-12-27
Maintenance Olaparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.
Gynecologic oncology, 2018-10
Improved survival with adjuvant brachytherapy in stage IA endometrial cancer of unfavorable histology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-07-10
Randomized Phase II Trial of Carboplatin-Paclitaxel Versus Carboplatin-Paclitaxel-Trastuzumab in Uterine Serous Carcinomas That Overexpress Human Epidermal Growth Factor Receptor 2/neu.
International journal of radiation oncology, biology, physics, 1994-06-15
Combined-modality therapy of esophageal cancer with radiotherapy, etanidazole, and cisplatin-fluorouracil, with or without surgery: neurotoxicity, other toxicities and outcome.
International journal of radiation oncology, biology, physics, 2010-12-01
Dose-volume analysis of radiation pneumonitis in non-small-cell lung cancer patients treated with concurrent cisplatinum and etoposide with or without consolidation docetaxel.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010-06
Phase II trial of combined modality therapy with myeloid growth factor support in patients with locally advanced non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands), 2021 Jan 30
Safety of G-CSF with concurrent chemo-radiotherapy in limited-stage small cell lung cancer - Secondary analysis of the randomised phase 3 CONVERT trial.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2015-12-15
Prospective Validation of Pooled Prognostic Factors in Women with Advanced Cervical Cancer Treated with Chemotherapy with/without Bevacizumab: NRG Oncology/GOG Study.
N. Engl. J. Med., 2019 Sep 28
Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer.
N Engl J Med, 2019 Dec 19
Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer.
Science (New York, N.Y.), 2017-07-28
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade.
The New England journal of medicine, 2018-05-31
Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-12-20
Safety and Efficacy of Pembrolizumab in Advanced, Programmed Death Ligand 1-Positive Cervical Cancer: Results From the Phase Ib KEYNOTE-028 Trial.
The New England journal of medicine, 2006-01-05
Intraperitoneal cisplatin and paclitaxel in ovarian cancer.
Lancet Oncol, 2013 Sep
Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial.
J. Clin. Oncol., 2019 Apr 19
Advanced Epithelial Ovarian Cancer: Do More Options Mean Greater Benefits?
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2015-01-01
Impact of the addition of carboplatin and/or bevacizumab to neoadjuvant once-per-week paclitaxel followed by dose-dense doxorubicin and cyclophosphamide on pathologic complete response rates in stage II to III triple-negative breast cancer: CALGB 40603 (Alliance).
Lancet Oncol., 2014-06-01
Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2017-02-01
Efficacy of Neoadjuvant Carboplatin plus Docetaxel in Triple-Negative Breast Cancer: Combined Analysis of Two Cohorts.
Ann Surg Oncol, 2014 Aug
Efficacy of adjuvant radiation therapy in the treatment of soft tissue sarcoma of the extremity: 20-year follow-up of a randomized prospective trial.
Cancer,
A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma.
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting, 2018-05-23
Neoadjuvant Chemotherapy, Concurrent Chemoradiation, and Adjuvant Chemotherapy for High-Risk Extremity Soft Tissue Sarcoma.
Acta Oncol, 2017 Apr 21
Predictive and prognostic factors associated with soft tissue sarcoma response to chemotherapy: a subgroup analysis of the European Organisation for Research and Treatment of Cancer 62012 study.
Lancet Oncol., 2017 Sep 04
Gemcitabine and docetaxel versus doxorubicin as first-line treatment in previously untreated advanced unresectable or metastatic soft-tissue sarcomas (GeDDiS): a randomised controlled phase 3 trial.
Lancet Oncol., 2012 Sep 04
Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial.
Cancer management and research, 2017
Clinical features, diagnostic challenges, and management strategies in checkpoint inhibitor-related pneumonitis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-06-10
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline.
Br. J. Cancer, 2009 Feb 17
Extended weekly dose-dense paclitaxel/carboplatin is feasible and active in heavily pre-treated platinum-resistant recurrent ovarian cancer.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2011-05
2010 Gynecologic Cancer InterGroup (GCIG) consensus statement on clinical trials in ovarian cancer: report from the Fourth Ovarian Cancer Consensus Conference.
Lancet Oncol., 2020 Mar 03
Risk of COVID-19 for patients with cancer.
Lancet, 2020 Feb 07
Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.
Lancet Oncol., 2020 Feb 14
Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China.
Ann. Oncol., 2020 Mar 26
Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China.
Current treatment options in oncology, 2018-11-15
Using PARP Inhibitors in the Treatment of Patients With Ovarian Cancer.
Gynecol. Oncol., 2019 Oct 17
Choosing wisely: Selecting PARP inhibitor combinations to promote anti-tumor immune responses beyond BRCA mutations.
J Oncol Pharm Pract, 2020 Jan 06
PARP-inhibitor potpourri: A comparative review of class safety, efficacy, and cost.
Gynecologic oncology, 2007-05
Squamous cell carcinoma arising in mature cystic teratoma of the ovary: a case series and review of the literature.
Gynecol Oncol Rep, 2016 Dec 18
An ovarian mature cystic teratoma evolving in squamous cell carcinoma: A case report and review of the literature.
Gynecol Oncol,
Squamous cell carcinoma arising in mature cystic teratoma of the ovary.
BMC Cancer, 2019 Mar 11
Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review.
Clin Cancer Res, 2017 Sep 27
The Driver Mutational Landscape of Ovarian Squamous Cell Carcinomas Arising in Mature Cystic Teratoma.
Oncogene, 2020 Mar 02
XCL1 expression correlates with CD8-positive T cells infiltration and PD-L1 expression in squamous cell carcinoma arising from mature cystic teratoma of the ovary.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-01
Phase III randomized study of cisplatin versus paclitaxel versus cisplatin and paclitaxel in patients with suboptimal stage III or IV ovarian cancer: a gynecologic oncology group study.
Lancet, 2019 Nov 29
Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal carcinoma treatment (ICON8): primary progression free survival analysis results from a GCIG phase 3 randomised controlled trial.
Lancet Oncol., 2014 Feb 28
Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trial.
Lancet,
Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin, and cisplatin in women with ovarian cancer: the ICON3 randomised trial.
J Clin Oncol, 2020 Feb 10
Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update.
Gynecologic oncology, 2009-08
Impact on survival of 12 versus 3 monthly cycles of paclitaxel (175 mg/m2) administered to patients with advanced ovarian cancer who attained a complete response to primary platinum-paclitaxel: follow-up of a Southwest Oncology Group and Gynecologic Oncology Group phase 3 trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-04-01
Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum.
Lancet Oncol.,
Rucaparib for patients with platinum-sensitive, recurrent ovarian carcinoma (ARIEL3): post-progression outcomes and updated safety results from a randomised, placebo-controlled, phase 3 trial.
Br. J. Cancer, 2018 Oct 24
Long-term efficacy, tolerability and overall survival in patients with platinum-sensitive, recurrent high-grade serous ovarian cancer treated with maintenance olaparib capsules following response to chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011-04-10
Natural history of paclitaxel-associated acute pain syndrome: prospective cohort study NCCTG N08C1.
Cancer journal (Sudbury, Mass.), 2007
The Paclitaxel acute pain syndrome: sensitization of nociceptors as the putative mechanism.
The journal of supportive oncology, 2003
Glutamine does not prevent paclitaxel-associated myalgias and arthralgias.
J Clin Oncol,
Use of gabapentin in the prevention of taxane-induced arthralgias and myalgias.
Breast Cancer (Dove Med Press), 2017 Jan 23
Docetaxel-associated myalgia-arthralgia syndrome in patients with breast cancer.
J. Clin. Oncol., 2011 Mar 28
Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin versus concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix.
BMC Cancer, 2017 Apr 28
Long-term results of early adjuvant concurrent chemoradiotherapy for high-risk, early stage uterine cervical cancer patients after radical hysterectomy.
Clinical cancer research : an official journal of the American Association for Cancer Research, 2018-02-15
Mutations in Homologous Recombination Genes and Outcomes in Ovarian Carcinoma Patients in GOG 218: An NRG Oncology/Gynecologic Oncology Group Study.
N Engl J Med, 2019 Dec 19
Veliparib with First-Line Chemotherapy and as Maintenance Therapy in Ovarian Cancer.
J Clin Oncol, 2020 Apr 10
Germline and Somatic Tumor Testing in Epithelial Ovarian Cancer: ASCO Guideline.
Nature, 2013-05-02
Integrated genomic characterization of endometrial carcinoma.
Gynecologic oncology, 2019-09
Comprehensive genomic profiling of recurrent endometrial cancer: Implications for selection of systemic therapy.
F1000Res, 2019 Jun 12
Recent advances in endometrial cancer: a review of key clinical trials from 2015 to 2019.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013-09-01
Reduction of cancer-related fatigue with dexamethasone: a double-blind, randomized, placebo-controlled trial in patients with advanced cancer.
Journal of the National Cancer Institute, 2013-08-21
Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010-02
Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-07-20
Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.
Lancet Oncol., 2018 Feb 12
Adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): final results of an international, open-label, multicentre, randomised, phase 3 trial.
Ann. Rheum. Dis., 2019 Sep 20
Immune checkpoint inhibitor-induced inflammatory arthritis persists after immunotherapy cessation.
Blood, 2008-05-15
Development and validation of a predictive model for chemotherapy-associated thrombosis.
The New England journal of medicine, 2019-02-21
Rivaroxaban for Thromboprophylaxis in High-Risk Ambulatory Patients with Cancer.
J Thromb Haemost, 2019 Jul 28
The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH.
N Engl J Med, 2018 Dec 04
Apixaban to Prevent Venous Thromboembolism in Patients with Cancer.
Obstet Gynecol,
Long-term mortality associated with oophorectomy compared with ovarian conservation in the nurses' health study.
JAMA,
Association of Menopausal Hormone Therapy With Breast Cancer Incidence and Mortality During Long-term Follow-up of the Women's Health Initiative Randomized Clinical Trials.
Cancer Prev Res (Phila), 2019 Aug 16
Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study.
Lancet, 2010-03-06
Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial.
Lancet,
Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma.
Gynecol Oncol Rep, 2020 Jan 30
Dedifferentiated endometrioid adenocarcinoma of the uterus: A case series and review of literature.
World J Surg Oncol, 2017 Jan 10
Dedifferentiated endometrioid carcinoma of the uterus : report of four cases and review of literature.
The New England journal of medicine, 2018-07-12
Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.
Breast J, 2019 Jul 04
Ovarian remnant syndrome in an aromatase inhibitor-treated patient with BRCA2 mutation following bilateral oophorectomy.
Lancet Oncol, 2021 Mar 18
Olaparib tablets as maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a final analysis of a double-blind, randomised, placebo-controlled, phase 3 trial.
Lancet Oncol, 2015 Jun 23
Standard chemotherapy with or without bevacizumab for women with newly diagnosed ovarian cancer (ICON7): overall survival results of a phase 3 randomised trial.
N. Engl. J. Med.,
Improved survival with bevacizumab in advanced cervical cancer.
Lancet (London, England), 2017-10-07
Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial (Gynecologic Oncology Group 240).
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2019-06-10
Efficacy and Safety of Pembrolizumab in Previously Treated Advanced Cervical Cancer: Results From the Phase II KEYNOTE-158 Study.
J Clin Oncol, 2019 Nov 04
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Lancet Oncol, 2021 Apr 09
Efficacy and safety of tisotumab vedotin in previously treated recurrent or metastatic cervical cancer (innovaTV 204/GOG-3023/ENGOT-cx6): a multicentre, open-label, single-arm, phase 2 study.
Gynecologic oncology, 2016-01
Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases.
Gynecol Oncol, 2020 Jul 9
Small cell carcinoma of the ovary hypercalcemic type (SCCOHT): Comprehensive management of a newly diagnosed young adult.
Gynecol Oncol, 2020 Jul 25
Dose-intensive regimen treatment for small-cell carcinoma of the ovary of hypercalcemic type (SCCOHT).
The New England journal of medicine, 2016-07-14
Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting.
Practical radiation oncology, 2021 Sep-Oct
Medical Marijuana for Cancer: Perspective From a Radiation Oncologist Credentialed to Certify in Pennsylvania.
Palliative medicine, 2022 Mar 31
Efficacy of medicinal cannabis for appetite-related symptoms in people with cancer: A systematic review.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 Mar 28
Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer.
Pract Radiat Oncol, 2022 Oct 22
Radiation Therapy for Endometrial Cancer: An American Society for Radiation Oncology Clinical Practice Guideline.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000-04
Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix.
Gynecologic oncology, 1998-08
Radiation therapy of pelvic recurrence after radical hysterectomy for cervical carcinoma.
EMBO Mol Med, 2020 Apr 29
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases.
J Oncol, 2020 Jun 24
Pathogenesis, Assessments, and Management of Chemotherapy-Related Cognitive Impairment (CRCI): An Updated Literature Review.
Journal for immunotherapy of cancer, 2017-11-21
Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group.
J Immunother Cancer, 2021 Feb
Success and failure of additional immune modulators in steroid-refractory/resistant pneumonitis related to immune checkpoint blockade.
J Natl Compr Canc Netw,
NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities, Version 1.2020.
Ann Oncol,
Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
J Immunother Cancer,
Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes.
J Immunother Cancer,
Real-world insights on preferred treatments for steroid-refractory immune checkpoint inhibitor-induced pneumonitis.
J Clin Oncol, 2021 Dec 20
Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update.
J Natl Compr Canc Netw,
Management of Immunotherapy-Related Toxicities, Version 1.2022, NCCN Clinical Practice Guidelines in Oncology.
Gynecologic oncology, 2019-06
Low-volume disease in endometrial cancer: The role of micrometastasis and isolated tumor cells.
Gynecol Oncol, 2021 Mar 05
Sentinel lymph node (SLN) isolated tumor cells (ITCs) in otherwise stage I/II endometrioid endometrial cancer: To treat or not to treat?
Ann Oncol, 2021 Mar 18
Association of Clinical Factors and Recent Anti-Cancer Therapy with COVID-19 Severity among Patients with Cancer: A Report from the COVID-19 and Cancer Consortium.
J Clin Oncol, 2020 Jul 14
Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy in Survivors of Adult Cancers: ASCO Guideline Update.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-06-20
Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline.
J Clin Oncol, 2019 Dec 19
Dietary Supplement Use During Chemotherapy and Survival Outcomes of Patients With Breast Cancer Enrolled in a Cooperative Group Clinical Trial (SWOG S0221).
Ann Oncol,
Chemotherapy-induced peripheral neuropathy: ice, compression, both, or neither?
The Lancet. Oncology, 2014-02
Chemotherapy for isolated locoregional recurrence of breast cancer (CALOR): a randomised trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-06-01
Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2004
Role of surgical resection for lung, liver, and central nervous system metastases in patients with gynecological cancer: a literature review.
Cochrane Database Syst Rev, 2011 Jun 15
Adjuvant progestagens for endometrial cancer.
Arch Gynecol Obstet, 2009 Mar 21
Splenic metastasis from endometrial carcinoma: report of a case and review of literature.
Strahlenther Onkol, 2011 Nov 17
Hematogenous metastases in patients with Stage I or II endometrial carcinoma.
Gynecol Oncol Res Pract, 2016 Jun 17
Surgical management of lung, liver and brain metastases from gynecological cancers: a literature review.
Indian J Med Paediatr Oncol,
Oligometastatic breast cancer: A mini review.
J Clin Oncol, 2020 Sep 29
Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209).
Gynecologic oncology, 2011-07
Neuroendocrine tumors of the gynecologic tract: A Society of Gynecologic Oncology (SGO) clinical document.
BMC Cancer, 2018 May 04
Neuroendocrine carcinoma of the cervix: a systematic review of the literature.
Gynecol Oncol, 2017 Sep 24
Cycles of cisplatin and etoposide affect treatment outcomes in patients with FIGO stage I-II small cell neuroendocrine carcinoma of the cervix.
JAMA oncology, 2019-03-01
Association of Chemotherapy for Solid Tumors With Development of Therapy-Related Myelodysplastic Syndrome or Acute Myeloid Leukemia in the Modern Era.
N Engl J Med, 2021 Sep 18
Pembrolizumab for Persistent, Recurrent, or Metastatic Cervical Cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2011-10
Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study.
Journal of oncology practice, 2019-01
Putting Integrative Oncology Into Practice: Concepts and Approaches.
Support Care Cancer, 2021 Aug 16
MASCC antiemetics in advanced cancer updated guideline.
Arthritis Rheumatol, 2021 Apr 01
Inflammatory Myositis in Cancer Patients Receiving Immune Checkpoint Inhibitors.
Int J Gynecol Cancer, 2020 Dec 18
ESGO/ESTRO/ESP guidelines for the management of patients with endometrial carcinoma.
N Engl J Med, 2022 Jan 19
Lenvatinib plus Pembrolizumab for Advanced Endometrial Cancer.
Gynecol Oncol, 2020 Nov 05
Uterine serous carcinoma: Molecular features, clinical management, and new and future therapies.
Cancer Cell, 2020 Oct 08
Open Notes in Oncology: Patient versus Oncology Clinician Views.
J Gen Intern Med, 2021 Feb 02
Words Matter: What Do Patients Find Judgmental or Offensive in Outpatient Notes?
JAMA Netw Open, 2020 Jun 01
Frequency and Types of Patient-Reported Errors in Electronic Health Record Ambulatory Care Notes.
Practical radiation oncology, 2019-03
Impact of Open Access to Physician Notes on Radiation Oncology Patients: Results from an Exploratory Survey.
Cancer chemotherapy and pharmacology, 2003-07
Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial.
J Oncol Pharm Pract, 2009 Sep 16
A comparison of the rates of cisplatin (cDDP)--induced nephrotoxicity associated with sodium loading or sodium loading with forced diuresis as a preventative measure.
Cancer Treat Rep,
Cisplatin hydration with and without mannitol diuresis in refractory disseminated malignant melanoma: a southwest oncology group study.
Ann Pharmacother, 2012 Jan 31
The role of mannitol as a nephroprotectant in patients receiving cisplatin therapy.
The Lancet. Oncology, 2019-05
Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial.
Nat Commun, 2021 May 03
Molecular and clinical determinants of response and resistance to rucaparib for recurrent ovarian cancer treatment in ARIEL2 (Parts 1 and 2).
Blood Adv, 2017 Jun 22
Ovarian vein thrombus: to treat or not to treat?
Cancer medicine, 2018-06
Adjuvant chemotherapy in patients with operable granulosa cell tumors of the ovary: a surveillance, epidemiology, and end results cohort study.
Gynecologic oncology, 2015-03
The role of systemic chemotherapy in the management of granulosa cell tumors.
Gynecologic oncology, 1999-02
Bleomycin, etoposide, and cisplatin combination therapy of ovarian granulosa cell tumors and other stromal malignancies: A Gynecologic Oncology Group study.
Gynecol Oncol, 2017 May 19
Ovarian granulosa cell tumor: A National Cancer Database study.
N Engl J Med, 2009 Jun 10
Mutation of FOXL2 in granulosa-cell tumors of the ovary.
Cancer Res, 2020 Jul 08
Mutant FOXL2 Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors.
J Clin Oncol, 2022 Jun 06
A Randomized, Phase III Trial to Evaluate Rucaparib Monotherapy as Maintenance Treatment in Patients With Newly Diagnosed Ovarian Cancer (ATHENA-MONO/GOG-3020/ENGOT-ov45).
Journal of hospital medicine, 2018-08-01
Things We Do For No Reason: Neutropenic Diet.
Front Oncol, 2022 Mar 09
Neutropenic Diet Cannot Reduce the Risk of Infection and Mortality in Oncology Patients With Neutropenia.
BMJ Support Palliat Care, 2022 Jul 08
Neutropenic versus regular diet for acute leukaemia induction chemotherapy: randomised controlled trial.
Nutr Cancer, 2019 Oct 12
Lack of Efficacy of the Neutropenic Diet in Decreasing Infections among Cancer Patients: A Systematic Review.
Gynecologic oncology, 2017-02
Phase II study of irinotecan in combination with bevacizumab in recurrent ovarian cancer.
Lancet Oncol, 2014 Sep 28
Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randomised phase 3 trial.
Lancet Oncol, 2012 Nov 16
Continuation of bevacizumab after first progression in metastatic colorectal cancer (ML18147): a randomised phase 3 trial.
Lancet Oncol,
Carboplatin-based doublet plus bevacizumab beyond progression versus carboplatin-based doublet alone in patients with platinum-sensitive ovarian cancer: a randomised, phase 3 trial.
J Immunother Cancer,
Rechallenge patients with immune checkpoint inhibitors following severe immune-related adverse events: review of the literature and suggested prophylactic strategy.
Arthritis care & research, 2018-10
Impact of Radiation Therapy on Scleroderma and Cancer Outcomes in Scleroderma Patients With Breast Cancer.
Gynecologic oncology, 1994-04
A phase II trial of ifosfamide and mesna in patients with advanced or recurrent mixed mesodermal tumors of the ovary previously treated with platinum-based chemotherapy: a Gynecologic Oncology Group study.
J Clin Oncol, 2022 Mar 20
Randomized Phase III Trial of Paclitaxel and Carboplatin Versus Paclitaxel and Ifosfamide in Patients With Carcinosarcoma of the Uterus or Ovary: An NRG Oncology Trial.
Crit Rev Oncol Hematol, 2018 Dec 24
Ovarian carcinosarcoma: Current developments and future perspectives.
PLoS One, 2017 Jan 26
Clinical Significance of Programmed Death Ligand‑1 and Intra-Tumoral CD8+ T Lymphocytes in Ovarian Carcinosarcoma.
Gynecol Oncol Res Pract, 2018 Aug 18
Response to pembrolizumab in a heavily treated patient with metastatic ovarian carcinosarcoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-08-01
Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1-Positive Endometrial Cancer: Results From the KEYNOTE-028 Study.
The Lancet. Oncology, 2015-11
Lenvatinib, everolimus, and the combination in patients with metastatic renal cell carcinoma: a randomised, phase 2, open-label, multicentre trial.
N Engl J Med, 2021 Feb 13
Lenvatinib plus Pembrolizumab or Everolimus for Advanced Renal Cell Carcinoma.
J Clin Oncol, 2020 Mar 13
Lenvatinib Plus Pembrolizumab in Patients With Advanced Endometrial Cancer.
N Engl J Med, 2015 Apr 19
Pembrolizumab versus Ipilimumab in Advanced Melanoma.
Gynecol Oncol, 2021 May 03
Toxicity and efficacy of the combination of pembrolizumab with recommended or reduced starting doses of lenvatinib for treatment of recurrent endometrial cancer.
Gynecologic oncology, 2019-04
Association of chemotherapy and radiotherapy sequence with overall survival in locoregionally advanced endometrial cancer.
Gynecol Oncol, 2019 Oct
Sequencing of therapy in women with stage III endometrial carcinoma receiving adjuvant combination chemotherapy and radiation.
Gynecol Oncol, 2020 Aug 15
Adjuvant radiation followed by chemotherapy is associated with improved overall survival in endometrial cancer.
Int J Gynecol Cancer, 2021 Mar 26
Sequencing chemotherapy before radiotherapy for women with stage IIIC endometrial cancer.
Gastroenterology, 1993-06
Hepatoprotective properties of ursodeoxycholic acid.
Gastroenterology, 1991 Jul
Evidence for a direct hepatoprotective action of ursodeoxycholic acid in primary human hepatocytes.
Z Naturforsch C J Biosci, 2002 Mar-Apr
Prophylactic effect of aqueous propolis extract against acute experimental hepatotoxicity in vivo.
Immunopharmacol Immunotoxicol, 2003 Nov
Hepatoprotective effect of baicalin, a major flavone from Scutellaria radix, on acetaminophen-induced liver injury in mice.
Exp Toxicol Pathol, 2002 Feb
Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.
Biochem Biophys Res Commun, 1999 Sep 24
Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants.
Ital J Gastroenterol Hepatol, 1998 Dec
Amantadine hydrochloride decreases serum ALT activity without effects on serum HCV-RNA in chronic hepatitis C patients.
Chem Biol Interact, 2001 Dec 21
Vitamin E succinate protects hepatocytes against the toxic effect of reactive oxygen species generated at mitochondrial complexes I and III by alkylating agents.
Cochrane Database Syst Rev, 2016 Jun 09
First-line chemotherapy in low-risk gestational trophoblastic neoplasia.
BMC Cancer, 2021 Oct 18
Direct comparisons of efficacy and safety between actinomycin-D and methotrexate in women with low-risk gestational trophoblastic neoplasia: a meta-analysis of randomized and high-quality non-randomized studies.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-02-01
Randomized double-blind trial of estrogen replacement therapy versus placebo in stage I or II endometrial cancer: a Gynecologic Oncology Group Study.
Obstet Gynecol, 1998 Oct
Meta-analysis of estrogen therapy in the management of urogenital atrophy in postmenopausal women: second report of the Hormones and Urogenital Therapy Committee.
Acta Oncol, 2019 Apr 08
Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy.
Haematologica, 2019 Jan 03
The Khorana score for prediction of venous thromboembolism in cancer patients: a systematic review and meta-analysis.
Gynecol Oncol, 2022 Oct 15
Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Am J Surg Pathol, 2015 Nov
Gastric-type Endocervical Adenocarcinoma: An Aggressive Tumor With Unusual Metastatic Patterns and Poor Prognosis.
Eur J Surg Oncol, 2022 Mar 25
Analysis of postoperative adjuvant therapy in 102 patients with gastric-type mucinous carcinoma of the uterine cervix: A multi-institutional study.
Gynecologic oncology, 2003-06
Radiation therapy with and without extrafascial hysterectomy for bulky stage IB cervical carcinoma: a randomized trial of the Gynecologic Oncology Group.
American journal of obstetrics and gynecology, 2007-11
Radiation therapy with or without weekly cisplatin for bulky stage 1B cervical carcinoma: follow-up of a Gynecologic Oncology Group trial.
BMC Cancer, 2021 Oct 11
Clinicopathological features and outcomes in gastric-type of HPV-independent endocervical adenocarcinomas.
Gynecol Oncol, 2019 Jan 29
Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study.
Int J Gynecol Cancer, 2018 Jan
Chemoresistance of Gastric-Type Mucinous Carcinoma of the Uterine Cervix: A Study of the Sankai Gynecology Study Group.
BMB Rep, 2022 Sep
Untold story of human cervical cancers: HPV-negative cervical cancer.
J Gynecol Oncol, 2019 Sep 17
Completion hysterectomy after chemoradiotherapy for locally advanced adeno-type cervical carcinoma: updated survival outcomes and experience in post radiation surgery.
Eur Heart J, 2022 Nov 01
2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).
JACC CardioOncol, 2022 Dec 20
Immune Checkpoint Inhibitor Myocarditis Treatment Strategies and Future Directions.
Pediatric blood & cancer, 2018-02
Consensus and controversies regarding the treatment of rhabdomyosarcoma.
Gynecologic oncology, 2004-03
A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study.
Int J Gynecol Cancer, 2022 Dec 20
Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program.
J Clin Oncol, 2020 Aug 04
Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy.
Int J Gynecol Cancer, 2020 Oct 12
PORTEC-4a: international randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer.
Int J Gynecol Cancer, 2021 Jun
Adjuvant brachytherapy for FIGO stage I serous or clear cell endometrial cancer.
J Contemp Brachytherapy, 2020 Feb 28
The role of vaginal brachytherapy in stage I endometrial serous cancer: a systematic review.
Gynecol Oncol, 2022 Nov 15
Molecular testing for endometrial cancer: An SGO clinical practice statement.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006-03-01
Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer.
Clinical Medicine Insights. Oncology, 2022 Jun 24
Combination of Palliative Thoracic Radiotherapy With Bevacizumab for Stage IV Nonsquamous NSCLC: Is There Any Impact of Time Interval on Survival?
N Engl J Med, 2023 Mar 27
Pembrolizumab plus Chemotherapy in Advanced Endometrial Cancer.
N Engl J Med, 2023 Mar 27
Dostarlimab for Primary Advanced or Recurrent Endometrial Cancer.
Journal of clinical oncology : Official Journal of the American Society of Clinical Oncology, 2023 Oct 21
Durvalumab Plus Carboplatin/Paclitaxel Followed by Maintenance Durvalumab With or Without Olaparib as First-Line Treatment for Advanced Endometrial Cancer: The Phase III DUO-E Trial.
Gynecologic oncology, 2006-10
Final analysis of RTOG 9708: adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer.
Int J Gynecol Pathol, 2021 Jul 13
Defining Substantial Lymphovascular Space Invasion in Endometrial Cancer.
Br J Cancer, 2018 Oct 25
Ten-year results of the PORTEC-2 trial for high-intermediate risk endometrial carcinoma: improving patient selection for adjuvant therapy.
Int J Radiat Oncol Biol Phys, 2023 Mar 08
Is Substantial Lymphovascular Space Invasion Prognostic in Patients With Pathologically Lymph Node-Negative Endometrial Cancer?
Gynecol Oncol, 2020 Jul 25
Is the risk of substantial LVSI in stage I endometrial cancer similar to PORTEC in the North American population? - A single-institution study.
Translational cancer research, 2021 May
Combination radiation and immunotherapy in gynecologic malignancies-a comprehensive review.
Lancet (London, England), 2023 Oct 20
Pembrolizumab plus trastuzumab and chemotherapy for HER2-positive gastric or gastro-oesophageal junction adenocarcinoma: interim analyses from the phase 3 KEYNOTE-811 randomised placebo-controlled trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 Oct 23
Efficacy and Safety of Trastuzumab Deruxtecan in Patients With HER2-Expressing Solid Tumors: Primary Results From the DESTINY-PanTumor02 Phase II Trial.
Eur Heart J, 2022 Jan 31
Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement.
J Am Heart Assoc, 2020 Jan 21
Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment.
Circulation, 2020 Jun 15
Major Adverse Cardiovascular Events and the Timing and Dose of Corticosteroids in Immune Checkpoint Inhibitor-Associated Myocarditis.
Journal of the National Cancer Institute, 2016-06
An Ethical Framework for Allocating Scarce Life-Saving Chemotherapy and Supportive Care Drugs for Childhood Cancer.
Pediatrics, 2014 Feb 02
Chemotherapy drug shortages in pediatric oncology: a consensus statement.
N. Engl. J. Med.,
Pembrolizumab for Early Triple-Negative Breast Cancer.
The Journal of urology, 2018-12
Impact of the Number of Cycles of Platinum Based First Line Chemotherapy for Advanced Urothelial Carcinoma.
N. Engl. J. Med.,
Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer.
Lancet Oncol., 2014 Feb 18
Definitive chemoradiotherapy with FOLFOX versus fluorouracil and cisplatin in patients with oesophageal cancer (PRODIGE5/ACCORD17): final results of a randomised, phase 2/3 trial.
NEJM Evidence, 2022 Jun 1
Durvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer
Br J Cancer, 2014 Apr 15
Gemcitabine-oxaliplatin plus prednisolone is active in patients with castration-resistant prostate cancer for whom docetaxel-based chemotherapy failed.
Cancer, 2011-06-15
Frontline treatment of localized osteosarcoma without methotrexate: results of the St. Jude Children's Research Hospital OS99 trial.
Eur J Cancer, 2017 Nov 28
Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study.
N. Engl. J. Med., 2019 Sep 28
Nivolumab plus Ipilimumab in Advanced Non-Small-Cell Lung Cancer.
Lancet Oncol, 2021 Jan 18
First-line nivolumab plus ipilimumab combined with two cycles of chemotherapy in patients with non-small-cell lung cancer (CheckMate 9LA): an international, randomised, open-label, phase 3 trial.
J Clin Oncol, 2021 Apr 19
Five-Year Outcomes With Pembrolizumab Versus Chemotherapy for Metastatic Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score ≥ 50.
J Clin Oncol, 2003 Jul 01
Gemcitabine plus vinorelbine compared with cisplatin plus vinorelbine or cisplatin plus gemcitabine for advanced non-small-cell lung cancer: a phase III trial of the Italian GEMVIN Investigators and the National Cancer Institute of Canada Clinical Trials Group.
JAMA, 2019 Apr 16
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
Head Neck, 2016 Mar 29
Effectiveness of honey on radiation-induced oral mucositis, time to mucositis, weight loss, and treatment interruptions among patients with head and neck malignancies: A meta-analysis and systematic review of literature.
The Lancet. Oncology, 2017-05
Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial.
Gynecol Oncol Rep, 2021 Jun 09
Radiation therapy for vaginal and perirectal lesions in recurrent ovarian cancer.
J Obstet Gynaecol Res, 2019 Mar 06
Radiotherapy for isolated recurrent epithelial ovarian cancer: A single institutional experience.
The Lancet. Oncology, 2012-04
Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies.
Cell reports. Medicine, 2022 Mar 15
A multi-level investigation of the genetic relationship between endometriosis and ovarian cancer histotypes.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2005 Nov 11
Malignant extraovarian endometriosis: a review.
Cancer causes & control : CCC, 2017 Mar 15
Endometriosis and risk of ovarian and endometrial cancers in a large prospective cohort of U.S. nurses.
International journal of cancer, 2011 Apr 04
Frequency of mismatch repair deficiency in ovarian cancer: a systematic review This article is a US Government work and, as such, is in the public domain of the United States of America.
Frontiers in oncology, 2021 Jun 03
A Review of the Clinical Characteristics and Novel Molecular Subtypes of Endometrioid Ovarian Cancer.
The New England journal of medicine, 2018-11-15
Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer.
Int J Gynecol Cancer, 2021 Sep 07
ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer.
J Clin Oncol, 2023 Jan 30
Efficacy and Safety of Mirvetuximab Soravtansine in Patients With Platinum-Resistant Ovarian Cancer With High Folate Receptor Alpha Expression: Results From the SORAYA Study.
The lancet. Diabetes & endocrinology, 2019 Aug 22
Combination denosumab and high dose teriparatide for postmenopausal osteoporosis (DATA-HD): a randomised, controlled phase 4 trial.
J Immunother Cancer, 2022 Mar
Translational randomized phase II trial of cabozantinib in combination with nivolumab in advanced, recurrent, or metastatic endometrial cancer.
Journal of the National Cancer Institute, 2018-01-01
Use of Alternative Medicine for Cancer and Its Impact on Survival.
JAMA oncology, 2021 May 01
Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.
Antioxidants & redox signaling, 2020 Aug 07
Vitamin C and Cell Death.
Journal of experimental & clinical cancer research : CR, 2020 Oct 07
Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas.
BMJ (Clinical research ed.), 2000 Nov 04
The role of complementary and alternative medicine.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2023 Jul 24
Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022 Sep 09
Overall Survival With Maintenance Olaparib at a 7-Year Follow-Up in Patients With Newly Diagnosed Advanced Ovarian Cancer and a BRCA Mutation: The SOLO1/GOG 3004 Trial.
Rheumatology (Sunnyvale, Calif.), 2015 May 07
Polymyalgia Rheumatica and its Association with Cancer.
Annals of the rheumatic diseases, 2013 Jul 10
Is cancer associated with polymyalgia rheumatica? A cohort study in the General Practice Research Database.
Clin Transl Radiat Oncol, 2018 Jan 11
The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2022 Mar
Neoadjuvant chemotherapy followed by surgery in cervical cancer: past, present and future.
The Lancet. Oncology, 2017-01
Rucaparib in relapsed, platinum-sensitive high-grade ovarian carcinoma (ARIEL2 Part 1): an international, multicentre, open-label, phase 2 trial.
International journal of radiation oncology, biology, physics, 2024 Oct 23
Hormone Replacement Therapy in Patients with Gynecologic Cancer and Radiation-Induced Premature Ovarian Insufficiency.
Eur. J. Cancer, 2008 Apr 02
Phase III randomised study to evaluate the role of adjuvant pelvic radiotherapy in the treatment of uterine sarcomas stages I and II: an European Organisation for Research and Treatment of Cancer Gynaecological Cancer Group Study (protocol 55874).
Lancet (London, England), 2024 Mar 20
Pembrolizumab or placebo with chemoradiotherapy followed by pembrolizumab or placebo for newly diagnosed, high-risk, locally advanced cervical cancer (ENGOT-cx11/GOG-3047/KEYNOTE-A18): a randomised, double-blind, phase 3 clinical trial.
Lancet (London, England), 2023 Dec 01
Atezolizumab plus bevacizumab and chemotherapy for metastatic, persistent, or recurrent cervical cancer (BEATcc): a randomised, open-label, phase 3 trial.
Eur. J. Cancer, 2010 Jul 07
Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer--results from two randomised studies.
J Clin Oncol, 2022 Jan 06
Pembrolizumab in Patients With Microsatellite Instability-High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study.
Int J Radiat Oncol Biol Phys, 2020 Mar 1
A Phase II Trial of Stereotactic Ablative Radiation Therapy as a Boost for Locally Advanced Cervical Cancer.
Radiation oncology (London, England), 2021 Jun 14
A novel external beam radiotherapy method for cervical cancer patients using virtual straight or bending boost areas; an in-silico feasibility study.
Seminars in radiation oncology, 2016-04
Small Bowel Dose Tolerance for Stereotactic Body Radiation Therapy.
Advances in radiation oncology, 2017
Late small bowel toxicity after aggressive abdominopelvic intensity modulated radiation therapy.
Gynecologic oncology, 2020 Sep 24
Dose-escalated intensity modulated radiation therapy in patients with locally-advanced vulvar cancer - does it increase response rate?
Gynecologic oncology, 2018-10
Human papillomavirus infection mediates response and outcome of vulvar squamous cell carcinomas treated with radiation therapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024 Apr 04
Phase II Trial of Cisplatin, Gemcitabine, and Intensity-Modulated Radiation Therapy for Locally Advanced Vulvar Squamous Cell Carcinoma: NRG Oncology/GOG Study 279.
N Engl J Med, 2019 02 28
A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms.
N Engl J Med, 2023 Mar 2
Neoadjuvant-Adjuvant or Adjuvant-Only Pembrolizumab in Advanced Melanoma.
The New England journal of medicine, 2024 Jun 02
Neoadjuvant Nivolumab and Ipilimumab in Resectable Stage III Melanoma.
Gynecologic oncology, 2019-03
Outcomes after definitive re-irradiation with 3D brachytherapy with or without external beam radiation therapy for vaginal recurrence of endometrial cancer.
JAMA oncology, 2024 Jul 01
Stereotactic Ablative Radiotherapy for Gynecological Oligometastatic and Oligoprogessive Tumors.
Annals of oncology : official journal of the European Society for Medical Oncology, 2024 Sep 14
Niraparib first-line maintenance therapy in patients with newly diagnosed advanced ovarian cancer: final overall survival results from the PRIMA/ENGOT-OV26/GOG-3012 trial.
Gynecol Oncol, 2021 Feb 1
Mutated p53 portends improvement in outcomes when bevacizumab is combined with chemotherapy in advanced/recurrent endometrial cancer: An NRG Oncology study.
Therapeutic advances in medical oncology, 2024 Sep 28
Safety of dostarlimab in combination with chemotherapy in patients with primary advanced or recurrent endometrial cancer in a phase III, randomized, placebo-controlled trial (ENGOT-EN6-NSGO/GOG-3031/RUBY).
Gynecologic oncology, 2019 Oct 31
Carboplatin-paclitaxel compared to Carboplatin-Paclitaxel-Bevacizumab in advanced or recurrent endometrial cancer: MITO END-2 - A randomized phase II trial.

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