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Medical Oncology

Pediatric Oncology   

Questions discussed in this category

In a patient with HR B ALL and severe pancreatitis due to peg-asparaginase, how do you assess the impact of peg discontinuation on risk of relapse?
For patients not on study, would you consider replacing missed doses of peg with a non-asparaginase based chemotherapy?
2 Answers available
Do you switch from imatinib to another TKI in patients with chronic phase CML who develop renal insufficiency?
There are conflicting reports whether it contributes to renal insufficiency. If you do switch, what is your preferred TKI in this scenario?
2 Answers available
For patients with newly diagnosed brain metastases without a history of seizure activity, do you routinely start anti-seizure medication?
If so, how long do you continue medication and when do you discontinue? Does treatment with surgical resection versus radiation alone change your man...
1 Answer available
When treating patients with immune checkpoint inhibitors, do you routinely check markers of endocrinopathies such as TSH/ACTH, or only when a patient has symptoms?
If so, how often do you check these labs?
1 Answer available
What is the role of local control +/- whole lung irradiation in a patient with relapsed/refractory Ewing sarcoma to the hilum plus multiple lung nodules?
Patient initially achieved CR with VAC-IE with resolution of presumed lung mets and 100% necrosis in LLE primary tumor on BKA. Then was NED again afte...
2 Answers available
What are your top takeaways from ASH 2022?
8 Answers available
How do you approach hormone replacement therapy for premenopausal patients following pelvic radiation therapy?
How is your approach different from or similar to those who undergo surgical menopause? 
1 Answer available
Do you do prophylactic LP/IT chemotherapy in high risk APML prior to starting consolidation?
1 Answer available
How would you work up a mildly neutropenic patient (ANC >800) with family history of neutropenia and personal history of occasional mouth sore?
What are indications to order gene mutation studies (e.g. ELANE) and how would it help the patient?
1 Answer available
What are some alternatives to dexamethasone for brain edema in patients who are allergic, have an intolerance, or refuse the medication?
5 Answers available
What chemotherapy regimen would you use for a testicular cancer patient in need of BEPx3 but unable to use platinum based chemotherapy regimen due to cochlear implants?
2 Answers available
How do you manage prophylactic antimicrobial medications in patients who undergo ATG/cyclosporine/eltrombopag induction for severe aplastic anemia?
What would you recommend within the first year after ATG and thereafter if still maintained on cyclosporine?
1 Answer available
What is your approach to BK hemorrhagic cystitis not responding to cidofovir?
1 Answer available
Which patients with acute promyelocytic leukemia do you consider maintenance after completing consolidation?
1 Answer available
How do you discern whether elevated liver enzymes are from immunotherapy versus chemotherapy when a patient is on combination chemo/immunotherapy?
2 Answers available
What would your next line treatment be for a patient previously treated with repeat resection, craniospinal irradiation, and initial cisplatin/vincristine/CCNU with medulloblastoma?
What would be your next treatment for a young adult patient with medulloblastoma refractory to repeat resection, craniospinal irradiation, and initial...
1 Answer available
Which chemo regimen, if any, would you use as adjuvant treatment in a young patient with primary malignant thyroid teratoma?
Would surgical margins, evidence of angiolymphatic spread, number of lymph nodes removed during surgery inform your decision? 
1 Answer available
Should post-transplant cyclophosphamide be utilized for all matched unrelated donor peripheral blood stem cell transplants for hematologic malignancy?
If not, how do you choose GVHD prophylaxis regimen? Is there a preference?
2 Answers available
What is your approach to adjuvant treatment for stage IA small cell carcinoma of the ovary, hypercalcemic type, after fertility sparing surgical staging?
1 Answer available
How would you approach cytopenias 5 weeks after initial dosing in a young patient with MDS treated with Azacitadine as a bridge to transplant?
E.g. would you dose-reduce or continue at same dose? Baseline ANC was in the normal range
1 Answer available
When do you refer patients for germline testing when somatic tumor testing is negative for actionable mutations?
How reliable is somatic testing to detect an underlying germline predisposition?
2 Answers available
Is cross reactivity low enough to try cisplatin as an alternative for patients who experience hypersensitivity reaction to carboplatin?
Is skin testing advised prior to trialing alternative?
2 Answers available
How would you approach an early stage II unfavorable Hodgkins lymphoma following 6 cycles ABVD with persistent Deauville 5 with negative biopsy?
iPET2 and iPET4 showed Deauville 5 response. CT biopsy after 4 cycles was negative. Patient is currently scheduled for 2 additional cycles of ABVD.
1 Answer available
How would you treat a locally-recurrent extraosseous (pulmonary) Ewing sarcoma?
Ewing sarcoma of the right lung, status post bi-lobectomy and adjuvant VDC/IE, with recurrence 6 years in the right lung only. He has reached a cumula...
1 Answer available
What is your approach in a fit patient, advanced stage, bulky classical Hodgkin lymphoma who has decreased disease burden in areas but a persistent, hypermetabolic (Deauville 5) anterior mediastinal mass following two cycles of AAVD?
2 Answers available
What are your recommendations for a male patient who was recently started on imatinib and wants to conceive?
4 Answers available
What is your institutional approach to a restrictive “neutropenic diet”?
3 Answers available
How would you work up and manage persistent lymphopenia in an asymptomatic patient?
ALC<200
1 Answer available
Do you recommend starting an antiplatelet for primary prophylaxis in post splenectomy thrombocytosis given there is some increased risk of venous thrombosis?
If so, what platelet count threshold would you use? Would age impact your decision? Would you do a bone marrow to rule out primary MPD in adults if th...
1 Answer available
What is the benefit of cytoreduction with Hydroxyurea for patients with newly diagnosed chronic phase CML with a WBC count >100 prior to the initiation of a TKI?
1 Answer available
How do you manage AEDs in patients with malignant brain tumors?
Do you ever add prophylactic Keppra (levetiracetam) for glioblastoma patients without a seizure history based on data such as this study (nature.com) ...
5 Answers available
What is your first line of therapy for refractory Hodgkin lymphoma in an AYA patient?
1 Answer available
How do you prescribe a steroid taper for radiation and checkpoint inhibitor related pneumonitis?
I've seen a handful of fatal radiation pneumonitis associated with rapid steroid tapers by the non-treating physicians. How do you recommend prescribi...
1 Answer available
How do you manage a patient with a history of high-risk leukemia who has increasing loss of donor chimerism in the post-transplant setting in the absence of disease relapse?
How does graft function play into your decision making? How do you utilize post allogeneic transplant chimerism in clinical practice? Do you obta...
1 Answer available
At what platelet count would you feel comfortable dosing aspirin 81 mg for coronary artery disease in a patient with ITP?
Presuming strong indication for ASA - eg history of NSTEMI
1 Answer available
How has the virtual aspect of tumor boards impacted their educational quality in the Covid-19 era?
1 Answer available
Is there any benefit to transplant patients with Ph+ ALL who have achieved MRD-negativity?
1 Answer available
How do you manage insomnia in cancer patients that is refractory to traditional sleep aides?
In patients who continue to have insomnia despite diphenhydramine, benzos, and trazodone, are there other evidence based treatments that are helpful?
4 Answers available
How do you manage real-time release of pathology and radiology results to oncology patients following enaction of the CURES act?
1 Answer available
Do you routinely offer antiviral prophylaxis for patients receiving chemoimmunotherapy?
If so, what regimen do you utilize?
1 Answer available
In a patient with stage 1 mixed germ cell tumor who cleared tumor markers post-orchiectomy but with subsequent rise to borderline abnormal within 6 weeks, would you treat with 3 cycles BEP as for S1 disease?
If serum markers were normal, how strongly do you consider 1 cycle of BEP for embryonal predominant pathology? 
1 Answer available
Why do we use dexamethasone for CNS edema and prednisone for pneumonitis?
Is this an artifact of what agent prior clinical trials used or something to do with mechanism of action (ie less mineralocorticoid effect of dex)?
1 Answer available
For a young male with Stage III intermediate risk NSGCT with active 1 ppd smoking history but normal PFTs and DLCO results, would you still consider use of BEP x 4?
VIP can be considered, but given complex psychosocial issues and limited community cancer treatment resources, this question is being asked. 
2 Answers available
Are there best practices or data regarding the use of open notes among oncology patients?
What is the impact among patients and providers? Has your documentation been adjusted now that patients can readily review?
2 Answers available
How do you approach heparin management in patients who have suprathetherapeutic Xa levels on minimal heparin?
1 Answer available
Do you treat stage 1 non-seminoma differently if there is a component of embryonal carcinoma?
1 Answer available
Do you routinely check Pulmonary function testing prior to each cycle of BEP for young patients with testicular cancer with no pulmonary risk factors?
NCCN guidelines state check at baseline and then as clinically indicated. Some other sources state, can check prior to each cycle of BEP?  What ...
2 Answers available
How do you incorporate denosumab into the surgical management of giant cell tumor of bone?
Does the degree of resectability affect your management?
2 Answers available
Do you recommend routine use of Evusheld for pre-exposure prophylaxis for patients on immunosuppression?
Does treatment with B-cell depletion and/or negative anti-spike antibody status despite COVID mRNA vaccination influence your decision?
1 Answer available
How do you approach very treatment-refractory ITP?
Such as the case in which a patient is unresponsive to steroids, IVIG, TPO-agonist, rituximab, splenectomy, and even fostamitinib.
1 Answer available
How do you manage drug-induced thrombocytopenia when the implicated drug is essential?
e.g. DITP from eptifibatide after a cardiac intervention
1 Answer available
For treatment of ITP, what would you add to dexamethasone to achieve the fastest recovery in a patient waiting for a procedure?
IVIG, TPO, or other agents?
1 Answer available
How do you approach therapy for a patient with stage IIIA NSGCT who received 4 cycles of EP followed by RPLND which revealed residual mixed teratoma and embryonal carcinoma?
Given persistent embryonal histology on RPLND, do you favor observation or TIP/VIP? What do you use to guide your decision?
1 Answer available
What features help distinguish thyroid myopathy from immune checkpoint inhibitor-associated myopathy?
1 Answer available
What is your strategy for breakthrough chemotherapy induced N&V in patients receiving highly emetogenic chemotherapy and already received a NK-1 antagonist, 5-HT3 antagonist, dexamethasone, and olanzapine?
2 Answers available
How would you treat a young patient with classical intermediate-risk Hodgkin lymphoma who has an underlying DNA repair-deficiency disorder, such as congenital mismatch repair disorder or ataxia telangiectasia?
How does your treatment approach vary depending on the underlying predisposition?
1 Answer available
How do you approach relapsed idiopathic HLH?
2 Answers available
How will you use Pola-R-CHP in the frontline treatment of DLBCL?
Given the POLARIX study data presented at ASH 2021, will this replace R-CHOP as the standard of care therapy in your practice? If not, how will y...
2 Answers available
What are contraindications for growth factors in patients with hematologic malignancies?
2 Answers available
Do you routinely check platelet counts after COVID-19 vaccines in patients with chronic ITP?
1 Answer available
How do you manage a patient with superficial venous thrombosis with close proximity (<3 cm) to deep veins and an inherited thrombophilia ?
Would you offer indefinite anticoagulation if the event is unprovoked and the patient has low bleeding risk? 
1 Answer available
What is the optimal age at which a patient with sickle cell disease should undergo allogeneic stem cell transplant?
1 Answer available
Is there experience/reports of using voxelotor in sickle cell patients who are Jehovah Witnesses with few crises but who have fatigue and/or dyspnea?
Also is there value in using voxelotor for the purpose of reducing hemolysis, and if so what parameters do you use to determine when to initiate voxel...
2 Answers available
What is your preferred approach for patients with anti-phospholipid syndrome with recurrent thrombosis on coumadin and LMWH?
1 Answer available
How would you approach moderate neutropenia (ANC < 1000) in a solid organ transplant recipient?
Is there a particular sequence you would adjust contributing antirejection or antimicrobial medications? Is the use of G-CSF appropriate and at what c...
2 Answers available
What is the role of hydroxyurea in variant sickle cell genotypes?
Hydroxyurea is demonstrated to reduce complications and improve long-term outcomes in severe genotypes HbSS and sickle beta0 thalassemia. What clinica...
2 Answers available
In what circumstances would you give G-CSF to a patient with severe neutropenia and HLH?
1 Answer available
How do you approach conversations regarding discontinuation of transfusions in patients with advanced hematologic malignancies who are otherwise appropriate for hospice?
Are there other supportive care interventions that would otherwise be covered by hospice?
1 Answer available
Do you utilize D-dimer to inform anticoagulation duration in the treatment of VTE?
Provoked or unprovoked VTE: Do you use D-Dimer (or even repeat imaging to reassess residual clot) in any capacity to guide anticoagulation duration? E...
2 Answers available
How would you manage VTE in a patient with bleeding disorder such as hemophilia?
Have you used anticoagulants other than coumadin? Or is that the only appropriate agent given monitoring is based on PT/INR?
1 Answer available
How long should patients treated with frontline therapy for Hodgkin lymphoma wait before attempting to conceive a child?
Do your recommendations differ between those who receive ABVD and escalated BEACOPP? Do you recommend consultation with fertility specialists for all...
1 Answer available
What regimen would you offer a young patient with T-cell ALL who recurred a short time after allo-transplant and was initially treated with CALGB10403?
Especially with the current drug shortage of nelarabine.
2 Answers available
Would you start TKI therapy in a patient with new diagnosis of T-ALL without BCR-ABL gene rearrangement on FISH but found to have very low level p190 transcript on RT-PCR?
1 Answer available
How do you approach management of sickle cell patients who mistrust Western medicine and prefer naturopathic therapies?
While building a trusting patient-physician relationship, what therapies could be discussed that may be aligned with naturopathic medicine? (i.e. L-gl...
1 Answer available
How would you manage asymptomatic brain metastases from testicular non-seminomatous germ cell tumor with a choriocarcinomatous component?
2 Answers available
In which patients with oncologic or hematologic disorders are you recommending a 3rd dose of mRNA COVID vaccine?
2 Answers available
How do you approach treatment of a glioblastoma in pregnancy?
3 Answers available
Do you use premedications (acetaminophen, diphenhydramine) before pRBC and plt transfusions to prevent febrile nonhemolytic transfusion reactions and allergic reactions?
Does manipulation of blood products (leukoreduction, irradiated) affect your approach? There is growing evidence that routine premedication (at least ...
1 Answer available
What is the utility of immunotherapy in management of malignant peripheral nerve sheath tumors?
In particular, is there any data on the efficacy of Ipilimumab/Nivolumab?
1 Answer available
Under what circumstances would you consider anticoagulation in a young female patient with persistently elevated factor XI activity?
While this is a known risk factor for venous [Meijers et al NEJM 2000] and potentially arterial [Yang et al, Am J Clin Pathol 2006] thrombosis, it is ...
1 Answer available
How would you optimally manage a patient with a MDS/MPN overlap syndrome who has both transfusion-dependent anemia and marked thrombocytosis?
Would this change with someone who has a history of thrombosis (e.g. DVT/PE, MI, CVA)? Would this change with someone who is more fit vs more frail?
1 Answer available
Do you think there is any compelling data to support giving brentuximab as frontline therapy for pediatric patients with Hodgkin lymphoma?
Results of AHOD1331 are not yet known, but adults have started using Brentuximab upfront for high risk patients  
1 Answer available
How would you approach immunosuppression for patients with severe aplastic anemia who are not transplant or ATG candidates?
Such as patients who are frail, elderly, renally impaired? Would you consider sirolimus over cyclosporine or tacrolimus for safer nephrotoxicity prof...
1 Answer available
How long do you continue caplacizumab in relapsed refractory TTP?
How often do you monitor ADAMTS-13 levels off therapy?
1 Answer available
Are there any reasons to consider a prolonged course of steroids with taper over a shorter course of pulsed steroids in the treatment of ITP?
For example, do we prefer one regimen over the other in patients with a bleeding history or who have relapsed after a lengthy remission?
1 Answer available
What strategies have you found to be most effective in engaging PCPs in a primary-care or shared-care model of survivorship for pediatric and AYA patients who will receive ongoing care in their communities away from their primary oncology treatment site?
In follow up to @Jacqueline Casillas presentation at ASCO 2021 regarding models of survivorship care delivery for AYA patients. 
1 Answer available
With new data showing similar outcomes of mismatched unrelated donor and haploidentical related donor allogeneic transplants using post transplant cyclophosphamide, how does one decide which donor is optimal?
If given both options, which donor would one prefer: haploidentical related donor or 7/8 mismatched unrelated donor using post transplant cyclophospha...
1 Answer available
How is pediatric and young adult primary bone lymphoma risk stratified?
NCCN guideline V4.2021 DLBCL page BCEL-3 states stage I-II, bulky >= 7.5cm should be treated with 6 cycles of RCHOP, but most bone lymphoma studies...
1 Answer available
Would you consider bone marrow transplant in a pediatric patient with recurrent HLH with no identified exogenous trigger or HLH-associated mutation?
1 Answer available
How would you approach chronic isolated severe non-cyclic neutropenia with negative bone marrow and rheumatologic work-up?
Is there a role for empiric antibiotics if there is history of opportunistic infection?
1 Answer available
What dose of PEG-asparaginase do you recommend for teens with high BMI treated on a pediatric ALL regimen?
Would you plan straight pediatric dosing using 2500 Units/m2 or a cap of 3750 Units as used in some adult ALL regimens due to excess liver/pancreas to...
2 Answers available
How would you treat an advanced stage small-cell carcinoma of the ovary, hypercalcemic type? (SCCOHT)?
s/p optimal debulking. If this was an early-stage cancer would it change your adjuvant therapy recommendations?
1 Answer available
What treatment regimen would you recommend for young adults with platinum refractory relapsed germ cell tumors?
2 Answers available
How do you approach the use of low-dose aspirin for primary prevention in non-pregnant patients with SLE and positive aPL antibodies, without clinical criteria for APS?
Do you follow the 2019 EULAR Guidelines that SLE patients with asymptomatic, positive aPL should be on low-dose ASA?
1 Answer available
Should targeted therapies such as Brentuximab or Crizotinib be used in the upfront management of anaplastic large cell lymphoma in a pediatric or AYA patient?
1 Answer available
What is the role of targeted therapy in relapsed/refractory ALK+ anaplastic large cell lymphoma?
Would you use ALK inhibitors such as crizotinib based on recent phase II data? Are there any research efforts to combine ALK inhibitors with current ...
1 Answer available
Should high-dose methotrexate be used in the treatment of AYA patients with osteosarcoma?
1 Answer available
What is the preferred treatment approach for an AYA patient with intermediate to high risk Hodgkin lymphoma: The pediatric approach (ABVE-PC +/- radiation) or the adult approach (ABVD with possible escalation to BEACOPP)?
1 Answer available
When can defibrotide be discontinued before the 21-day treatment course is completed in a pediatric patient with SOS?
Do you always treat with the full 21-day treatment course, or can defibrotide be stopped if certain criteria are met sooner?
1 Answer available
How do you choose your systemic treatment for primary mediastinal grey zone lymphomas?
Do you prefer a cHL chemotherapy backbone or PMBL chemotherapy backbone?
3 Answers available
Should patients receive thrombophilia testing in the setting of a provoked VTE secondary to hormonal therapy/OCPs?
While thrombophilia testing is not routinely recommended prior to starting OCPs, how about after the development of a VTE?
2 Answers available
When do you refer AYA patients with newly diagnosed severe aplastic anemia for transplant?
Would you give a trial of IST first or immediately refer for SCT if the patient has matched siblings?
1 Answer available
Can an AYA patient with newly diagnosed AML safely sperm bank after starting cytoreduction with hydroxyurea or cytarabine?
2 Answers available
Would you offer immunotherapy for recurrent metastatic Ewing sarcoma if the tumor is MSI high or has high TMB?
2 Answers available
What are the current official guidelines regarding COVID-19 vaccination for patients with cancer or for hematologic conditions?
2 Answers available
Is a patient with secondary myeloid sarcoma a candidate for hematopoietic stem cell transplant?
2 Answers available
How would you time COVID-19 vaccination with someone on R-CHOP chemotherapy?
1 Answer available
How do you determine when to give a second CAR-T cell infusion to a pediatric or young adult patient with relapsed/refractory ALL?
2 Answers available
How would you approach the treatment of patients with von Willebrand disease or hemophilia A previously managed with intranasal DDAVP during the recall?
During the Stimate recall, how are we performing DDAVP challenges for newly diagnosed hemophilia A or von Willebrand disease?
1 Answer available
What is your response to the question, "Is this terminal?"
How do you "have the talk" in a way that is straightforward without emotionally crushing the patient?
8 Answers available
For AYA patients with early-stage Hodgkin's lymphoma being treated with ABVD, how many cycles of chemotherapy do you administer, and when can radiation be avoided?
Have the RAPID or CALGB 5064 studies changed your treatment approach?
2 Answers available
How do you counsel patients who are candidates for a clinical trial regarding their options?
Specifically, are there strategies you use to 1) empower patients to participate in decision-making and 2) reassure patients who may be skeptical?
2 Answers available
When should a gallium-dotatate scan be incorporated into the initial evaluation of a patient with a carcinoid tumor of the appendix?
1 Answer available
What are your thoughts on adding mycophenolate to steroids in the first line treatment of ITP based on the results of the FLIGHT trial?
Presented at ASH: FLIGHT trial
1 Answer available
How would you treat an adolescent or young adult with newly diagnosed hepatosplenic T-cell lymphoma?
1 Answer available
How do you approach a patient with multiply relapsed germ cell tumor with rising tumor markers but no obvious site of disease?
If standard of care BEP chemo, tandem transplant, and radiation to primary site have been done previously.
1 Answer available
For which rituximab infusion reaction symptoms do you consider it safe to re-challenge in the office with adjusted rates and pre-medications?
1 Answer available
Do hemoglobin S levels always correlate with SCD phenotype?
What is the lowest level you have seen with uncomplicated or complicated crises?
4 Answers available
What is your preferred formulation of parenteral iron?
There are various formulations of intravenous iron; each with varying costs, test dose requirement, elemental dose, and number or time of infusions ne...
1 Answer available
Do you re-test patients who test positive for COVID-19 during or prior to starting cancer treatment?
There are mixed recommendations about re-testing vs simply waiting for a quarantine period prior to resuming therapy. 
2 Answers available
How do you manage VTE in the setting of persistent severe thrombocytopenia?
Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?
3 Answers available
Is there any role for direct oral anticoagulants in the treatment of antiphospholipid syndrome?
What if this was "triple-negative" antiphospholipid syndrome?
2 Answers available
At what level of bone marrow disease would you agree to proceed with transplant for a patient with refractory AML?
I have heard <20% MRD. What about proceeding if patient is hypoplastic after chemotherapy?
1 Answer available
How do you approach the pharmacologic management of cancer-related fatigue?
After optimizing symptoms and reversible factors, and attempting cognitive-behavioral interventions and exercise, do you recommend pharmacologic agent...
2 Answers available
How would you approach therapy for a young, fit patient with alveolar rhabdomyosarcoma involving the anterior nasal vault/sinuses in the absence of available clinical trials?
Presented with mass projecting into right/left anterior ethmoid complex
1 Answer available
How would you treat a young patient with symptomatic Rosai-Dorfman disease who has recurrent, life-threatening pericardial and pleural effusions?
CT scans show omental and pelvic disease.
1 Answer available
How would you approach treatment in an otherwise young, fit patient with transformed AML currently in remission with a plan for transplant and was found to have an invasive fungal infection not amenable to resection upon recovery from induction?
Would you consider “bridging” therapy with something like an HMA?
1 Answer available
How would you approach langerhans cell histiocytosis involving a single bone site after resection?
1 Answer available
During induction therapy for acute leukemia, when do you decide to discontinue the antimicrobial prophylaxis?
Is it at neutrophil recovery, at documentation of CR on bone marrow biopsy, or is there a different point in time?
1 Answer available
What are the options of induction treatment of young AML patients who are on CRRT, continuous renal replacement therapy ?
1 Answer available
For pre-menopausal female patients who present with acute leukemia in need of urgent anti-neoplastic therapy, what is your preferred approach in effort to preserve fertility?
Does acute leukemia sub-type affect your decision? 
1 Answer available
How do you choose first or second-line systemic therapy for fibrolamellar hepatocellular carcinoma?
What are there most evidence-based options?
1 Answer available
How do you approach the decision of whether and when to initiate therapy in patients who remain COVID-19 positive >2 weeks after infection but are asymptomatic from the virus?
E.g. a patient with progression of their primary cancer but still is testing COVID19+ over a month after infection?
5 Answers available
When during ALL induction therapy are you checking for MRD?
1 Answer available
Should we be utilizing prophylactic G-CSF in our patients with intermediate risk of febrile neutropenia due to the COVID-19 pandemic?
Are you placing more weight on patient risk factors such as age >65 or co-morbidities?
2 Answers available
When will theMednet release an app for the iPhone?
2 Answers available
Would you hold rituximab for newly diagnosed B-cell lymphoma if the patient is COVID-19 positive?
What if the patient has a history of confirmed COVID-19 but has since recovered?
1 Answer available
What treatment would you offer a young pregnant woman with a symptomatic midline low grade glioma?
Discussion of treatment options for midline low-grade glioma causing life-altering symptoms in a pregnant patient to avoid teratogenicity.
2 Answers available
How do you determine whether to treat a young adult with stage IA Hodgkin Lymphoma with the adult or pediatric treatment paradigm?
At what age would you treat an early stage hodgkins lymphoma patient with ABVD + RT (adult treatment) vs OEPA x 2 or AV-PC x 3 (pediatric paradigm)?&n...
2 Answers available
Do you offer fertility preservation to patients prior to CAR-T therapy?
Do you limit it to post-pubertal patients? Do you offer it only if they will proceed with bone marrow transplantation after CAR-T?
1 Answer available
How do you treat a patient with a history of clinical stage IIb cN2, mixed germ cell embryonal carcinoma treated with BEP and RPLND five years ago, who now has signet ring cell adenocarcinoma with abdominal carcinomatosis with an unknown primary?
GI work up negative. NGS cancer type and isochromosome 12p ordered and pending. Pathology at RPLND was negative for cancer.  
3 Answers available
How do you decide the right time to transition to hospice?
Obviously, patient and caregiver preferences are paramount. But, what factors do you consider? Does expanded hospice (e.g., Medicare Care Choices) inf...
4 Answers available
What chemotherapy would you recommend for a patient with Ewing Sarcoma who has relapsed after being initially treated with vincristine/doxorubicin/ifosfamide?
2 Answers available
Are you altering your use of immune checkpoint inhibitors given the risk of immune-related pneumonitis and the COVID-19 outbreak?
2 Answers available
How should you manage a COVID-19 infected/suspected patient who is receiving chemotherapy and cannot interrupt or delay their cancer treatment?
2 Answers available
In light of promising results of hydroxychloroquine in COVID-19, should we consider using it prophylactically in cancer patients, especially if immunocompromised?
Acknowledging that there is no time for good trials yet in this setting
1 Answer available
How should you manage a coronavirus infected/suspected patient who is receiving radiotherapy and cannot interrupt or delay their cancer treatment?
How would you approach a patient who is receiving chemoRT but has confirmed COVID-19 with minor symptoms, as breaking treatment for 2 weeks quarantine...
7 Answers available
Should I wear gloves during a routine physical exam on an asymptomatic patient with no risk factors for COVID-19?
1 Answer available
How does the management of nasopharyngeal cancer in kids/young adults differ from adult patients?
-The data on induction for adult H&N ca has been mixed (excluded NPX) but recent data suggest a benefit for adult NPX. -Given that this is standa...
1 Answer available
What is the standard of care (if any) for pediatric desmoplastic round cell tumor?
Is there a role for immunotherapy outside of trial setting?
1 Answer available
When would you consider testicular RT prior to TBI for BMT?
What dose do you recommend?
1 Answer available
Should I treat a patient who doesn't know she has cancer?
My patient’s family has asked that I don’t tell her that she has metastatic cancer because it will devastate her. I am planning on palliat...
2 Answers available


Papers discussed in this category

JAMA,
The care of the patient.
Gynecol Oncol, 2019 Aug 16
Advanced communication: A critical component of high quality gynecologic cancer care: A Society of Gynecologic Oncology evidence based review and guide.
Cancer, 2004-08-15
The incidence of testicular recurrence in boys with acute leukemia treated with total body and testicular irradiation and stem cell transplantation.
Br. J. Haematol., 2003-11-01
Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia.
Br. J. Haematol., 1998-08-01
Total body irradiation-high-dose cytosine arabinoside and melphalan followed by allogeneic bone marrow transplantation from HLA-identical siblings in the treatment of children with acute lymphoblastic leukaemia after relapse while receiving chemotherapy: a Société Française de Greffe de Moelle study.
Cancer, 1990-11-15
Testicular relapse in children with acute nonlymphoblastic leukemia.
Radiother Oncol, 1990-01-01
Total body irradiation for bone marrow transplantation: the Memorial Sloan-Kettering Cancer Center experience.
Clin. Cancer Res.,
Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival.
Fertil. Steril., 2013 Sep 05
Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy: a committee opinion.
J. Clin. Oncol., 2019 Sep 25
Treatment of Childhood Nasopharyngeal Carcinoma With Induction Chemotherapy and Concurrent Chemoradiotherapy: Results of the Children's Oncology Group ARAR0331 Study.
Lancet Oncol., 2020 Feb 14
Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China.
Ann. Oncol., 2020 Mar 26
Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China.
J. Clin. Oncol., 2019 Sep 10
Positron Emission Tomography-Guided Treatment in Early-Stage Favorable Hodgkin Lymphoma: Final Results of the International, Randomized Phase III HD16 Trial by the German Hodgkin Study Group.
Journal of the National Cancer Institute, 2005-09-21
Second cancers among 40,576 testicular cancer patients: focus on long-term survivors.
Eur. J. Cancer,
Incidence of second primary cancer following testicular cancer.
Br. J. Cancer, 2007 Jan 30
Mortality and incidence of second cancers following treatment for testicular cancer.
American journal of hematology, 2018-08
Description and prognostic significance of the kinetics of minimal residual disease status in adults with acute lymphoblastic leukemia treated with HyperCVAD.
Blood, 2019-04-04
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403.
Am. J. Hematol., 2019 Nov 19
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