Benign Hematology   

Questions discussed in this category

- Dialysis catheter used for hemodialysis- RIJ thrombus in dialysis catheter was incidentally found- Patient asymptomatic with no prior history of VTE...

Do you recommend therapeutic phlebotomy to a certain Hct goal? Any strong evidence for thromboembolic risk related to erythrocytosis or if this is mit...

While benefits outweigh known harms and limited data, do you worry about vaccination in patients with a history of or active autoimmune cytopenias (e....

Assuming the patient is a candidate for all anticoagulation options (no mechanical valve, antiphospholipid syndrome, patient-specific contraindication...

Aside from addressing the underlying case, is there a role for phlebotomy in secondary polycythemia such as in COPD or post-renal transplant erythrocy...

While thrombophilia testing is not routinely recommended prior to starting OCPs, how about after the development of a VTE?

Especially in a triple-positive patient with an acute ischemic stroke who may have urgency for anticoagulation with high bleeding risk and severe thro...

While the CKD population is at high thrombotic and bleeding risk, would you consider anticoagulating a patient prophylactically if they had a history ...

The patient who has not responded to steroids, rituximab/bendamustine, and splenectomy?

Provoked or unprovoked VTE: Do you use D-Dimer (or even repeat imaging to reassess residual clot) in any capacity to guide anticoagulation duration? E...

In a patient with severe factor XII deficiency with a baseline prolonged PTT, what is the best method to monitor their ACT or heparin levels when on c...

Would you give a trial of IST first or immediately refer for SCT if the patient has matched siblings?

Would you consider high-dose dexamethasone (deliberating adverse effects of antenatal steroids) or move to next-line therapies?

Has your medical practice taken any steps either in community outreach or within the clinic to show support for this medically vulnerable population, ...

For a patient with low ferritin, but high TSAT?

Ref: EINSTEIN-CHOICE and AMPLIFY-EXT Would you approach this differently in patients with inherited thrombophilias?

For example, in cold agglutinin disease or AIHA, antibodies can be detected via DAT, but are often not observed on assays for monoclonal gammopathies.

During the Stimate recall, how are we performing DDAVP challenges for newly diagnosed hemophilia A or von Willebrand disease?

In low-risk patients (age < 40) or patients with very obvious causes of blood loss or iron deficiency (menorrhagia, pregnancy), do you routinely pe...

Given the high cost of eculizumab, are there patient characteristics that inform which patients, if any, should be on indefinite therapy versus a time...

Such as a patient who cannot tolerate oral iron and has had a anaphylaxis to intravenous iron

For example, a patient with hypogonadism unless it matters which organ is involved. Are other markers of iron storage useful in guiding therapy?

For example, a patient on cytoreductive therapy and aspirin BID, but suffers an arterial event, or a patient who is already on therapeutic anticoagula...

This is in the setting of a patient who is now on ruxolitinib with rising leukocytosis and thrombocytosis, but cannot be on aspirin due to recent blee...

In a patient with a medical or personal indication to induce oligomenorrhea/amenorrhea, how would you manage OCP therapy if a patient develops a VTE d...

If autoimmune neutropenia already suspected, is this test informative or unnecessary?

What is the lowest level you have seen with uncomplicated or complicated crises?

Do you go straight to TMPRSS2 genetic testing or what other lab testing (e.g. hepcidin) could be helpful?

There are various formulations of intravenous iron; each with varying costs, test dose requirement, elemental dose, and number or time of infusions ne...

If there are a low-risk patients who can be monitored, how would you do so? If unprovoked, would you consider stopping anticoagulation?

Should we use a different dose in critically ill patients in the ICU? When should we consider intermediate-dose anticoagulation?

Is there a preferred strategy of transfusional support versus reduced-dose anticoagulation during the duration of thrombocytopenia?

Hydroxyurea is demonstrated to reduce complications and improve long-term outcomes in severe genotypes HbSS and sickle beta0 thalassemia. What clinica...

Are there major differences in standard conditioning and/or GVHD prophylaxis regimens utilized? Does the non-relapse mortality different significantl...

While L-glutamine has minimal side effects and would likely be added after hydrea, how do you decide between the use of voxelotor and crizanlizumab?

Rituximab has entered the treatment algorithm in the first-line setting for the initial treatment of TTP. However, in remission, the role of adjuvant ...

What are your target goals during transfusion, either prophylactically or during acute complication? Does your management change between vaginal deliv...

Does your opinion change based on the specific underlying inherited thrombophilia? The original case was a central retinal artery occlusion in a patie...

Especially in a patient without hemophilia or thrombosis history?

Would you offer this routinely or only if specific complications arise, such as distal emboli?

In patients who are intolerant to hydroxyurea, anagrelide and interferon

Papers discussed in this category


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Blood, 2018 Jul 12

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Blood, 2015-05-28

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The New England journal of medicine, 2019-02-21

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The New England journal of medicine, 2017-02-02

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American journal of hematology, 2011-10

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Blood Cancer J, 2018 Feb 09

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Journal of thrombosis and haemostasis : JTH, 2018-06-07

American journal of hematology, 2008-08

Blood, 2010-07-22

Am J Gastroenterol,

Blood, 2017-07-20

Clin J Am Soc Nephrol, 2016 Oct 31

Blood, 2020 Dec 03

Rheumatol Int, 2019 Apr 30

Clin Exp Rheumatol, 2012 Sep 25

Wien Klin Wochenschr,

Leukemia, 2009-05

J Rheumatol, 2006 Jul 01

Semin Arthritis Rheum,

Haematologica, 2020

Nature, 2019-03

Blood, 2018 May 02

Journal of thrombosis and haemostasis : JTH, 2013-04-10

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J Natl Med Assoc,

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American journal of hematology, 2016-01

The Lancet. Haematology, 2015-09

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Transfus Med Rev,

Am J Kidney Dis, 2019 Aug 05